摘要
褪黑素是调节睡眠-觉醒周期的重要激素,可通过减少β-淀粉样蛋白沉积、抑制tau蛋白过磷酸化、减轻氧化应激损伤和炎症反应、改善胆碱能系统功能、调节神经元自噬等多种机制延缓阿尔茨海默病进展。本文综述褪黑素在阿尔茨海默病病理损害机制中的作用及其研究进展,以探究褪黑素在阿尔茨海默病治疗中的应用前景。
Melatonin is an important hormone regulating sleep and wake cycle,which can alleviate and delay the progression of Alzheimer's disease(AD)by reducing amyloid-βprotein(Aβ)deposition,inhibiting tau protein hyperphosphorylation,alleviating oxidative stress damage and inflammatory response,improving cholinergic system function,regulating neuronal autophagy,and other mechanisms.This article reviews the role of melatonin in the pathological injury mechanism of AD,so as to explore the clinical application prospect of melatonin in AD.
作者
姜佳凤
赵莲花
赵伟
JIANG Jia-feng;ZHAO Lian-hua;ZHAOWei(Department of Neurology,Tianjin TEDA Hospital,Tianjin 300457,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2023年第8期687-692,共6页
Chinese Journal of Contemporary Neurology and Neurosurgery