能谱CT成像预测肺腺癌EGFR突变的价值研究

A Survey About the Energy Spectral CT Imaging on the Prediction of EGFR Gene Mutations for Lung Adenocarcinoma Patients

目的 分析能谱CT成像与肺腺癌表皮生长因子受体(epidermal growth factor receptor,EGFR)突变状态之间的关系。方法 纳入2019年1月—2022年12月在福建医科大学附属协和医院收治的肺腺癌且对EGFR突变进行检测者120例,根据EGFR检测状态分为EGFR野生型(n=66)与EGFR突变型(n=54)。定量测量能谱CT的能谱曲线计算曲线斜率(curve slope,λHU)、水浓度、碘浓度、有效原子序数、CT 70 keV、CT 40 keV等定量参数指标,分析两组的能谱CT定量参数指标变化。结果 EGFR野生型的吸烟史、性别与EGFR突变型相比,差异有统计学意义(P <0.05);EGFR突变型在能谱CT静脉期、动脉期的定量参数包括λHU、有效原子序数、碘浓度、CT 70 keV值、CT 40 keV值等定量参数与EGFR野生型相比大幅度增高,差异有统计学意义(P <0.05);两组水浓度相比,差异无统计学意义(P> 0.05)。结论 能谱CT成像定量测量对肺腺癌表皮生长因子受体突变状态的预测具有较高的应用价值,可用于表皮生长因子受体的突变状态的预测诊断。

Objective To analyze the correlations of energy spectral CT imaging with epidermal growth factor receptor(EGFR) gene mutations in lung adenocarcinoma patients.Methods A total of 120 lung adenocarcinoma patients of undergoing the EGFR gene mutation examination from January 2019 to December 2022 of Fujian Medical University Union Hospital were selected and were assigned to EGFR wild-type group(n =66) and EGFR gene mutation group(n=54).The spectral curve was measured to analyze the curve slope(λHU),water and iodine concentrations,effective atomic number,CT 70 keV and CT 40 keV.The energy spectral CT quantitative parameters were observed.Results The smoking history and gender were found to be statistically significant between EGFR wild-type and EGFR gene mutation group(P<0.05).In the venous and arterial phase,the spectral CT quantitative parameters like curve slope(λHU),iodine concentrations,effective atomic number,CT 70 keV and CT 40 keV in EGFR gene mutation were higher than EGFR wild-type,with statistically significant difference(P<0.05),there was no significant difference in water concentration between the two groups(P>0.05).Conclusion The energy spectral CT quantitative parameters can make the effective prediction of EGFR gene mutation conditions for lung adenocarcinoma patients.