重庆市30~79岁居民高尿酸血症患病率及相关因素分析

Prevalence rate of hyperuricemia and its related factors among residents aged 30-79 years in Chongqing Municipality

目的分析重庆市30~79岁居民高尿酸血症患病率及相关影响因素,为开展高尿酸血症防治提供依据。方法调查对象来自重庆市13个区县30~79岁汉族常住居民,采用分层抽样的方法对调查对象进行问卷调查、体格检查和实验室检测。不同人群特征间高尿酸血症患病率比较采用χ^(2)检验,高尿酸血症相关影响因素采用多因素logistic回归分析。结果共计调查22449人。男性10512人(46.83%),女性11937人(53.17%)。高尿酸血症检出率为10.76%(95%CI:9.40%~12.12%),男性患病率(20.27%,95%CI:15.25%~25.29%)高于女性(2.38%,95%CI:0.95%~3.81%)(P<0.05)。多因素回归分析结果显示,男性(OR=24.621,95%CI:9.947~60.947)、低年龄(30~39岁)(OR=2.327,95%CI:1.471~3.681)、高社会经济地位(OR=1.537,95%CI:1.174~2.012)、不吸烟(OR=1.430,95%CI:1.153~1.773)、有害饮酒史(OR=1.458,95%CI:1.127~1.887)、中心性肥胖(OR=2.285,95%CI:1.885~2.771)、血脂异常(OR=2.440,95%CI:2.009~2.964)、高血压(OR=1.509,95%CI:1.236~1.843)、血糖正常(OR=1.677,95%CI:1.257~2.237)是高尿酸血症的危险因素。结论重庆市居民高尿酸血症患病率较低,重点应针对男性、青壮年、高社会经济地位、有害饮酒、肥胖、血脂异常、高血压患者等进行干预,降低高尿酸血症的发病风险。

Objective To analyze the prevalence rate of hyperuricemia and its related influencing factors among residents aged 30-79 years in Chongqing Municipality,and to provide a basis for performing prevention and control of hyperuricemia.Methods The subjects surveyed were recruited from the Han permanent residents aged 30-79 years in 13 districts or counties in Chongqing Municipality.A questionnaire survey,physical examinations and laboratory tests were performed among the subjects by using a stratified sampling method.Chi-square test was employed to compare the prevalence rates of hyperuricemia in populations with different features.The related factors affecting hyperuricemia were analyzed by multivariate logistic regression analysis.Results A total of 22,449 residents were surveyed in this study,including 10,512(46.83%)males and 11,937(53.17%)females.The detection rate of hyperuricemia was 10.76%(95%CI:9.40%-12.12%),and the prevalence rate of hyperuricemia was higher in males(20.27%,95%CI:15.25%-25.29%)than in females(2.38%,95%CI:0.95%-3.81%)(P<0.05).The results of multivariate logistic regression analysis revealed that males(OR=24.621,95%CI:9.947-60.947),young population(aged 30-39 years)(OR=2.327,95%CI:1.471-3.681),high socioeconomic status(OR=1.537,95%CI:1.174-2.012),non-smoking(OR=1.430,95%CI:1.153-1.773),having a history of harmful alcohol use(OR=1.458,95%CI:1.127-1.887),central obesity(OR=2.285,95%CI:1.885-2.771),hyperlipidemia(OR=2.440,95%CI:2.009-2.964),hypertension(OR=1.509,95%CI:1.236-1.843)and normal glucose(OR=1.677,95%CI:1.257-2.237)were risk factors for hyperuricemia.Conclusion The prevalence rate of hyperuricemia among the residents in Chongqing Municipality was low.Special attention should be paid to interventions targeting males,young population,residents with high socioeconomic status or harmful alcohol use,obese population and patients with hyperlipidemia or hypertension so as to reduce the risk of hyperuricemia.