肺癌根治术后CRP、IL-17与并发急性呼吸衰竭的相关性分析

Correlation analysis between CRP,IL-17 and acute respiratory failure after radical resection of lung cancer

目的 探讨肺癌根治术后C反应蛋白(CRP)、白介素-17(IL-17)与并发急性呼吸衰竭(ARF)的相关性。方法 选取2021年1月至2023年1月本院收治的86例肺癌根治术患者,对其临床资料进行回顾性分析,根据术后有无发生ARF分组,其中ARF组31例,未发生ARF共55例未发生急性呼吸衰竭组(NARF组),比较两组CRP、IL-17水平差异,分析CRP、IL-17与ARF的相关性。结果 两组TNM分期、病理类型、吸烟史各项基线资料相比无显著差异(P>0.05),ARF组COPD病史、手术方式、PaCO_(2)、PaO_(2)、CRP及IL-17水平与NARF组有显著差异(P<0.05);ARF组Ⅰ型患者CRP、IL-17水平均较Ⅱ型患者低(P<0.05);ARF组轻度、中度患者CRP、IL-17水平均较重度患者低(P<0.05);将COPD病史、手术方式、PaCO_(2)、PaO_(2)、CRP、IL-17作为自变量,建立Logistic回归方程,排除无关变量,结果显示CRP、IL-17为肺癌根治术后并发ARF的危险因素(P<0.05);Pearson相关性分析结果显示,CRP、IL-17与肺癌根治术后并发ARF呈正相关性(P<0.05)。结论 肺癌根治术后CRP、IL-17水平与并发ARF呈正相关性,通过检测CRP、IL-17水平便于临床医师预测ARF发生,从而指导采取针对性防治措施,积极预防ARF发生。

Objective To investigate the correlation analysis between C-reactive protein(CRP),interleukin-17(IL-17)and acute Respiratory failure(ARF)after radical resection of lung cancer.Methods 86 patients with lung cancer undergoing radical surgery admitted to our hospital from January 2021 to January 2023 were selected for a retrospective analysis of their clinical data.They were divided into groups based on whether or not ARF occurred after surgery.Among them,there were 31 cases in the ARF group and 55 cases without ARF(NARF group).The differences in CRP and IL-17 levels between the two groups were compared,and the correlation between CRP,IL-17,and ARF was analyzed.Results There was no significant difference in baseline data of TNM staging,pathological type,and smoking history between the two groups(P>0.05),while there were significant differences in COPD history,surgical methods,PaCO_(2),PaO_(2),CRP,and IL-17 levels between the ARF group and the NARF group(P<0.05).The levels of CRP and IL-17 in typeⅠpatients of ARF group were lower than those in typeⅡpatients(P<0.05).The levels of CRP and IL-17 in mild and moderate ARF patients were lower than those in severe ARF patients(P<0.05).Using the history of COPD,surgical methods,PaCO_(2),PaO_(2),CRP,and IL-17 as independent variables,a logistic regression equation was established to exclude irrelevant variables.The results showed that CRP and IL-17 were risk factors for ARF after radical lung cancer surgery(P<0.05).Pearson correlation analysis showed that CRP,IL-17 were positively correlated with postoperative ARF in lung cancer patients after radical surgery(P<0.05).Conclusion There is a positive correlation between the levels of CRP and IL-17 after radical lung cancer surgery and the occurrence of ARF.By detecting the levels of CRP and IL-17,clinical physicians can predict the occurrence of ARF,guide the adoption of targeted prevention and treatment measures,and actively prevent the occurrence of ARF.