肝硬化门静脉高压与营养不良的关系

Association between portal hypertension and malnutrition in liver cirrhosis

肝硬化的组织学结构异常常导致门静脉压力增加。门静脉高压是引发腹水、食管胃静脉曲张破裂出血、肝性脑病、肝肾综合征等肝硬化失代偿事件的主要原因。营养不良是肝硬化门静脉高压患者最常见的并发症之一。营养物质摄入减少、营养物质吸收障碍、高代谢、高氨血症和肠道菌群紊乱是导致肝硬化门静脉高压患者发生营养不良的主要原因。肝硬化门静脉高压与营养不良存在相互作用,本文就其相互影响方面的研究进展进行简要综述。

The abnormal histological structure of liver cirrhosis leads to the increase in portal venous pressure,and portal hypertension is the main cause of the decompensated events of liver cirrhosis such as ascites,gastroesophageal variceal bleeding,hepatic encephalopathy,and hepatorenal syndrome.Malnutrition is one of the most common complications in cirrhotic patients with portal hypertension,and the main causes of malnutrition include reduced nutrient intake,nutrient absorption disorders,hypermetabolism,hyperammonemia,and intestinal flora disturbance.There is an interaction between portal hypertension and malnutrition in liver cirrhosis,and this article briefly reviews the research advances in such interaction.