铜代谢失调与细胞损伤及肝病的关系

Association of copper metabolism disorder with cell damage and liver diseases

铜是人体必需的微量元素,在维持人体健康方面起着至关重要的作用。铜参与人体许多代谢过程,铜代谢失调会导致糖耐量受损和血脂异常等代谢障碍。肝脏在维持体内铜的平衡中起着核心作用,铜缺乏或过量会导致细胞损伤和肝功能障碍。近期有关铜代谢研究的最新进展揭示了铜代谢失调可通过影响氧化应激、蛋白酶体、铜死亡和血管生成引起细胞损伤,并有助于阐明由铜代谢失调引起的肝脏疾病和代谢障碍的假设机制。本文综述了近年来铜代谢失调在细胞损伤/死亡和慢性肝病(包括威尔逊氏病、非酒精性脂肪性肝病、肝细胞癌)中的研究进展,将有助于确定未来的研究重点。

Copper is an essential trace element in human body and plays an important role in maintaining health in humans.Copper is involved in various metabolic pathways in human body,and copper metabolism disorder may lead to metabolic disorders such as impaired glucose tolerance and dyslipidemia.The liver plays a key role in maintaining copper homeostasis,and copper deficiency or excess may cause cell damage and liver dysfunction.Recent studies on copper metabolism have shown that copper metabolism disorder may result in cell damage by affecting oxidative stress,proteasome,cuproptosis,and angiogenesis and help to clarify the assumed mechanisms of liver diseases and metabolic disorders due to copper metabolism disorder.This article reviews the recent research advances in copper metabolism disorder in cell damage/death and chronic liver diseases,including Wilson’s disease,nonalcoholic fatty liver disease,and hepatocellular carcinoma,which helps to identify future research priorities.