早发性卵巢功能不全的早期诊断和预防

Early diagnosis and prevention of premature ovarian insufficiency

早发性卵巢功能不全(premature ovarian insufficiency,POI)是指女性在40岁以前出现卵巢功能减退。POI可导致女性生育力下降及内分泌功能紊乱,诱发骨质疏松、心血管系统疾病、阿尔茨海默病等多种疾病的发生和发展,严重威胁女性健康。及时评估卵巢功能的状态对于早期诊断POI有重要意义,可帮助妇女适时开展雌孕激素治疗,预防相关疾病的发生和发展,合理指导女性进行生育规划,提高女性生活质量及健康水平。

Premature ovarian insufficiency(POI)refers to the loss of ovarian function before the age of 40,mainly manifested by abnormal menstruation(amenorrhea,rregular menstruation),increased gonadotropin levels(FSH>25 U/L),and fluctuated decrease of estrogen levels.POI can lead to the decline of female fertility and endocrine dysfunction,causing the occurrence and development of estrogen and progestogen treatment in time,osteoporosis,cardiovascular disease,Alzheimer's disease and other diseases,seriously threatening women's health.Timely assessment of ovarian function is of great significance for the early diagnosis of POI,which can help women to carry out and prevent related diseases,reasonably guide women to carry out fertility planning,and improve women's quality of life and health level.