青光眼睫状体炎综合征的研究进展

Research progress of Posner-Schlossman syndrome

青光眼睫状体炎综合征(PSS)是一种较少见、反复发作的自限性前葡萄膜炎,目前发病机制仍不明确,曾认为是前列腺素介导的炎症反应,近年发现与病毒感染、免疫遗传、血管内皮功能障碍等因素相关。临床上多单眼发病,发作时眼压升高,患眼轻度疼痛、视物不清、虹视等,较少引起视神经及视野损害。治疗以局部抗炎、降眼压为主,严重者可全身用药。如果PSS眼压升高药物不可控、发作频繁、病程长造成视神经损害、视野缺损,可进行手术治疗。对PSS早诊断、早治疗可以减少青光眼相关损害。本文将从多个方面论述PSS的研究现状,期望对本病的病因、发病机制及临床诊治方面提供参考。

Posner-Schlossman syndrome(PSS)is a sporadic and recurrent self-limiting anterior uveitis,and its pathogenesis remains unclear.It was considered to be a prostaglandin-mediated inflammatory response.In recent years,it has been found to be related to viral infection,immune genetics,vascular endothelial dysfunction,and other factors.Clinically,the disease is predominantly unilateral.The patients with PSS suffer from increased intraocular pressure,mild pain in the affected eye,as well as blurred vision,and irisopsia.Seldom damage to the optic nerve and visual field was reported.The commonly treatment of PSS is local medication,such as anti-inflammatory drugs and intraocular pressure lowering drugs;otherwise systemic medication can be employed in severe cases.Surgical treatment can be performed for PSS if uncontrolled intraocular pressure elevation,frequent attacks,and optic nerve damage and visual field defect due to prolonged disease course.Early diagnosis and treatment of PSS can effectively reduce glaucoma-related damages.This review discussed the research progress of PSS from various aspects,aiming to provide references for the etiology,pathogenesis,and clinical diagnosis and treatment of this disease.