肠道病毒及CKMB、WBC、AST、ALT与小儿手足口病的关系研究

A Study on the Relations of Enterovirus as Well as CKMB,WBC,AST and ALT to Infantile Hand-Foot-Mouth Syndrome

目的:探讨肠道病毒及肌酸激酶同工酶(CKMB)、白细胞(WBC)、谷草转氨酶(AST)、谷丙转氨酶(ALT)与小儿手足口病的关系。方法:选取2019-2022年我院收治的102例手足口病患儿,根据改良小儿手足口疾病严重程度评分分为观察组51例(评分≤60分,病情重)和对照组51例(评分>60分,病情轻),2组患儿均进行肠道病毒[肠道病毒71型(EV71)、柯萨奇病毒A16型(CoxA16)]核酸检测与血清CKMB、WBC、AST、ALT检测,比较2组患儿肠道病毒检出率及CKMB、WBC、AST、ALT水平,分析肠道病毒检出率及CKMB、WBC、AST、ALT水平与小儿手足口病的关系。结果:观察组患儿肠道病毒检出率明显高于对照组(P<0.05),观察组患儿血清CKMB、WBC、AST、ALT水平均高于对照组(P<0.05)。Pearson相关分析显示,肠道病毒检出率及CKMB、WBC、AST、ALT水平与小儿手足口病病情程度均呈正相关(P<0.05)。结论:肠道病毒检出率及CKMB、WBC、AST、ALT水平与小儿手足口病病情程度呈正相关,检测以上指标对辅助评估小儿手足口病病情程度具有重要临床意义。

Objective To probe into the relations of infantile hand-foot-mouth syndrome to enterovirus as well as CKMB,WBC,AST and ALT.Methods Enrolled 102 peditric patients with infantile hand-foot-mouth syndrome treated in authors'hospital(2019-2022),and according to their ratings on disease's severi-ty divided them into observation group(51 cases,the ratings<60 points,as severer pattern)and control group(51 cases,the ratings>60 points,as slighter pattern);both patients all received the nucleic acid de-tections of Human Enterovirus 71(EV71)and Coxsachievirus A16(CoxA16),as well as detections of ser-um CKMB,WBC,AST,and ALT levels;then,compared both groups'the detected rate of entrovirus,as well as the levels of CKMB,WBC,AST,and ALT,further analysed the relations between the detected rate,as well as levels of CKMB,WBC,AST,ALT to infantile hand-foot-mouth syndrome.Results In the de-tected rate,in the levels of CKMB,WBC,AST and ALT observation group was respectively higher,higher than control group(P<0.05);pearson relativity analysis showed infantile hand-foot mouth syndrome's conditions severity was proportionally related to all above-mentioned results(P<0.05).Conclusion The detected rate of entroviruses,as well as the levels of CKMB,WBC,AST and ALT are proportionally related to the condition's severity of infantile hand-foot-mouth syndrome,thus,the detections of above-mentioned items is helpful to evaluate its condition's severity.