高压氧联合奥沙利铂和卡培他滨化疗对胃癌患者的疗效及血清肿瘤标志物的影响

Efficacy of hyperbaric oxygen combined with oxaliplatin and capecitabine chemotherapy in patients with gastric cancer and its influence on serum tumor markers

目的探究高压氧(HBO)联合奥沙利铂+卡培他滨(XELOX)化疗方案对胃癌患者的疗效,及其对患者血清肿瘤标志物、免疫功能的影响。方法选取山西省人民医院2019年6月至2021年6月收治的胃癌患者86例,按照随机数字表法分为观察组和对照组,每组43例。对照组患者接受XELOX治疗,观察组患者接受HBO+XELOX治疗。比较2组患者近期临床疗效、不良反应及治疗前后血清肿瘤标志物与免疫功能水平。结果观察组和对照组近期疾病控制率(DCR)分别为79.07%和58.14%,差异有统计学意义(P<0.05)。治疗后2组患者血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原72-4(CA72-4)、CD8^(+)均降低,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均升高,且观察组变化程度高于对照组,差异均有统计学意义(P<0.05)。2组患者不良反应比较,差异无统计学意义(P>0.05)。结论 HBO联合XELOX方案治疗胃癌,可提高患者DCR,起到抗肿瘤效果,降低血清肿瘤标志物水平,提高免疫功能。

Objective To explore the efficacy of hyperbaric oxygen(HBO)combined with oxaliplatin and capecitabine(XELOX)chemotherapy in patients with gastric cancer,and its influence on serum tumor markers and immune function of the patients.Methods A total of 86 patients with gastric cancer admitted to Shanxi Provincial People's Hospital from June 2019 to June 2021 were selected and divided into observation group and control group according to the random number table method,with 43 cases in each group.The control group received XELOX treatment,and the observation group received HBO+XELOX treatment.The short-term clinical efficacy,adverse reactions,levels of serum tumor markers,and immune function before and after treatment were compared between the two groups.Results The short-term disease control rate(DCR)of the observation group and the control group was 79.07%and 58.14%,respectively,and the difference was statistically significant(P<0.05).After treatment,the levels of serum carcinoembryonic antigen(CEA),carbohydrate antigen19-9(CA19-9),carbohydrate antigen72-4(CA72-4),and CD8^(+)were decreased in the two groups,but the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)were increased in the two groups,and the changes in the observation group were greater than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion HBO combined with XELOX chemotherapy in the treatment of gastric cancer can improve DCR and reduce the levels of serum tumor markers,thus playing an anti-tumor effect and improving immune function.