急性一氧化碳中毒迟发性脑病患者假愈期时长与预后的关系研究

Relation between latent period and prognosis of delayed encephalopathy after carbon monoxide poisoning

目的研究急性一氧化碳中毒迟发性脑病患者假愈期时长与预后的关系。方法选取2019年3月至2020年11月解放军海军第九七一医院军事医学与特种学科收治的急性一氧化碳中毒迟发性脑病(DEACMP)患者48例,根据假愈期时长将患者分为假愈期≤15 d组(n=17)和假愈期>15 d组(n=31)。2组患者均进行不少于30次的高压氧及辅助药物治疗,记录其临床治疗变化和转归情况,并进行3个月以上的随访。采用Barthel指数及简易精神状态检查量表(MMSE)评分评估患者预后。结果假愈期>15 d组患者的Barthel指数及MMSE评分及治疗总有效率均明显高于假愈期≤15 d组,差异具有统计学意义(P<0.05)。结论 DEACMP患者的假愈期时长与预后关系密切。

Objective To study the relation between the latent period and the prognosis of patients with delayed encephalopathy after carbon monoxide poisoning(DEACMP).Methods A total of 48 patients with DEACMP treated in the Department of Military Medicine and Special Disciplines in the No.971 hospital of PLA Navy from March 2019 to November 2020 were selected and divided into two groups according to the length of their latent periods,one group with a latent period≤15 days(n=17),while the other group>15 days(n=31).The patients of the two groups underwent no less than 30 sessions of hyperbaric oxygen therapy and adjuvant drug therapy,and their clinical treatment changes and outcomes were recorded.Follow-up was carried out for more than three months.The prognosis was evaluated based on the Barthel index and the mini mental state examination(MMSE)score.Results The Barthel index,MMSE score,and the total effective rate of DEACMP patients with a latent period>15 days were significantly higher than those with a latent period≤15 days.The differences were statistically significant(P<0.05).Conclusion The length of the latent period of DEACMP patients after carbon monoxide poisoning is closely related to their prognosis.