子宫内膜异位症合并不孕患者的控制性卵巢刺激方案研究进展

Research Progress of the Controlled Ovarian Stimulation Protocols for Women with Endometriosis-Related Infertility

体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)是子宫内膜异位症(endometriosis,EMs)合并不孕的有效助孕方法,促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonist,GnRHa)超长方案进行长期降调节有助于改善EMs合并不孕患者的妊娠结局。近年来,越来越多的促排卵方案被应用于EMs合并不孕患者,如拮抗剂方案和高孕激素状态下促排卵方案等。这些方案展现了改善EMs合并不孕患者妊娠结局的潜力,但因EMs病因不明、分期复杂和临床的异质性,EMs合并不孕患者促排卵方案的选择尚存在争议,需要更多高质量的临床研究来验证不同个体的促排卵方案的有效性。

In vitro fertilization-embryo transfer(IVF-ET)is an effective method for the treatment of infertility combined with endometriosis(EMs).The ultra-long protocol of gonadotropin-releasing hormone agonist(GnRHa)for the long-term down-regulation of pituitary can help to improve pregnancy outcomes in infertile patients with EMs.In recent years,more and more ovulation induction protocols have been applied in patients with EMs-related infertility,such as gonadotropin-releasing hormone antagonist(GnRHA)protocol and progestin-primed ovarian stimulation(PPOS)protocol.These protocols have showed their potential in improving the pregnancy outcomes in patients with EMs-related infertility.However,the choice of ovulation induction protocols in patients with EMsrelated infertility is controversial due to unknown etiology,complex staging and clinical heterogeneity.It is necessary to conduct more high-quality clinical studies to validate the efficiency of these protocols in the different individuals.