尿微量白蛋白转铁蛋白α1-微球蛋白对过敏性紫癜肾损害患儿诊断的符合率及检出率分析

Urinary Microalbumin Transferrin α Analysis of Diagnostic Accuracy and Detection Rate of 1-microglobulin in Children with Henoch Schonlein Purpura Renal Damage

目的 探究尿微量白蛋白(Microalbuminuria,mALB)、转铁蛋白(transferrin,TRF)、α1-微球蛋白(α1-microglobulin,α1-MG)对过敏性紫癜肾损害患儿联合诊断的符合率及检出率。方法 选取郑州市中医院2015年1月~2022年1月期间接诊的126例过敏性紫癜患儿开展研究,根据有无肾损害分组:肾损害组(n=48例)、无肾损害组(n=78例),另外选择同期进行健康体检的儿童为健康体检组(n=51),均进行实验室检查,测定mALB、TRF、α1-MG水平变化,比较肾损害组、无肾损害组、B组mALB、TRF及α1-MG水平变化,在此基础上进一步分析mALB、TRF、α1-MG联合检测的诊断效果。结果 三组ALB、TRF及α1-MG水平较B组高,差异有统计学意义(P<0.05);mALB+TRF+α1-MG联合检测对肾损伤的阳性检出率93.75%较mALB检测79.17%、TRF检测72.92%、α1-MG检测58.33%高,差异有统计学意义(P<0.05);mALB、TRF、α1-MG联合检测对疾病的诊断敏感度、特异性较各单一指标高,差异有统计学意义(P<0.05)。结论 mALB、TRF、α1-MG联合诊断效果较高,可保证过敏性紫癜肾损害患儿诊断效果,同时动态监测各项指标水平变化,可有效判断患儿肾脏状况,以指导临床治疗,值得进行宣传、推广。

Objective To explore the urinary microalbuminuria(mALB),transferrin(TRF)α1-microglobulin(α1-microglobulin,α1-MG).Methods 126 children with Henoch Schonlein purpura who were hospitalized in Zhengzhou Hospital of Traditional Chinese Medicine from January 2015 to January 2022 were selected for the study.They were divided into kidney damage group(n=48 cases)and no kidney damage group(n=78 cases)according to whether they had kidney damage.In addition,children who had health checkups at the same time were selected as health checkups group(n=51).Laboratory tests were conducted to determine mALB,TRFα1-MG level change,compare mALB,TRF andα1-MG level change,further analyze mALB,TRFαDiagnostic effect of 1-MG combined detection.Results ALB,TRF andαThe level of 1-MG in group B was higher than that in group B(P<0.05);mALB+TRF+αThe positive detection rate of 1-MG combined detection for renal injury was 93.75%,79.17%compared with mALB detection,72.92%for TRF detectionαThe 1-MG test was 58.33%high,and the difference was statistically significant(P<0.05);mALB、TRF、αThe sensitivity and specificity of 1-MG combined detection were statistically significant(P<0.05).Conclusion mALB,TRFαThe 1-MG combined diagnosis has a high effect,which can ensure the diagnosis effect of children with Henoch Schonlein purpura renal damage.At the same time,the dynamic monitoring of the changes in the level of various indicators can effectively judge the renal status of children,so as to guide clinical treatment.It is worth promoting.