无排卵型月经失调的治疗中应用不同剂量的孕酮的疗效分析

Analysis of the Effect of Different Doses of Progesterone in the Treatment of Anovulatory Menstrual Disorder

目的 评估不同剂量孕酮应用在无排卵型月经失调治疗中的疗效。方法 纳入2020年6月—2021年11月接诊且行孕酮治疗的68例无排卵型月经失调患者,全部受试者以随机数字表法分为对照组(纳入34例,用药剂量为100mg/次)、观察组(纳入34例,用药剂量为200mg/次),评价组间月经量、月经周期、子宫内膜厚度、治疗相关参数、用药不良反应(ADR)、治疗效果。结果 (1)治疗前,组间月经量、月经周期、子宫内膜厚度无差异,P>0.05;治疗后,观察组月经量、月经周期、子宫内膜厚度更佳,P<0.05;(2)较之对照组,观察组子宫内膜厚度恢复正常时间、子宫彩超结果正常时间、阴道出血持续时间更少,P<0.05;(3)组间ADR相对比,观察组(17.65%)与对照组(8.82%)无差异,P>0.05;(4)在治疗效果方面,观察组(97.06%)高于对照组(82.35%),P<0.05。结论 对无排卵型月经失调患者行200mg/次孕酮治疗,不良反应少,且能尽快调节月经紊乱症状,改善正常月经量、月经周期、子宫内膜厚度,值得推广。

Objective To evaluate the efficacy of different doses of progesterone in the treatment of anovulatory menstrual disorders.Methods 68 patients with anovulatory menstrual disorder who were treated with progesterone from June 2020 to November 2021 were included.All the subjects were randomly divided into control group(34 patients were included,the dosage was 100mg/time)and observation group(34 patients were included,the dosage was 200mg/time).The menstrual volume,menstrual cycle,endometrial thickness,treatment related parameters,adverse drug reactions(ADR),and treatment effect between the groups were evaluated.Results(1)Before treatment,there was no difference in menstrual volume,menstrual cycle and endometrial thickness between the groups(P>0.05);After treatment,the menstrual volume,menstrual cycle and endometrial thickness in the observation group were better,P<0.05;(2)Compared with the control group,the time for endometrial thickness to return to normal,the time for normal results of color Doppler ultrasound,and the duration of vaginal bleeding in the observation group were less,P<0.05;(3)There was no difference in ADR between the observation group(17.65%)and the control group(8.82%),P>0.05;(4)In terms of therapeutic effect,the observation group(97.06%)was higher than the control group(82.35%),P<0.05.Conclusion 200 mg/time progesterone treatment for anovulatory menstrual disorder patients has few adverse reactions,and can regulate the symptoms of menstrual disorder as soon as possible,improve the normal menstrual volume,menstrual cycle and endometrial thickness,which is worth promoting.