中药类保健食品中地黄生熟异用的配方规律分析

Analysis of Formula Rules of Raw and Processed Rehmanniae Radix in Traditional Chinese Medicine Health Food

目的:分析地黄在中药类保健食品中生熟异用下的配方规律。方法:收集国家市场监督管理总局(SAMR)特殊食品信息查询平台公布的生、熟地黄保健食品数据,对其保健功能及中药组方等进行统计,运用Apriori算法和Kulc、不平衡比参数对地黄生熟异用的保健食品配方规律进行分析。结果:保健食品中,生地黄主要用于辅助降血糖,熟地黄主要用于增强免疫力、缓解体力疲劳、改善营养性贫血。在辅助降血糖类生地黄保健食品中,生地黄主要与补气药、补阴药、解表药、解热药配伍,代表性组合为生地黄-黄芪-苦瓜;在增强免疫力类熟地黄保健食品中,熟地黄主要与补气药、补血药、补阴药配伍,代表性组合为熟地黄-党参-阿胶;在缓解体力疲劳类熟地黄保健食品中,熟地黄主要与补气药、补阳药、补阴药配伍,代表性组合为熟地黄-人参-淫羊藿、熟地黄-人参-枸杞子;在改善营养性贫血类熟地黄保健食品中,熟地黄主要与补气药、补血药配伍,代表性组合为熟地黄-黄芪-阿胶、熟地黄-黄芪-当归。结论:地黄在保健食品中的使用遵循生熟异用的规律,在不同保健功能中,组方配伍基本符合中医理论和现代医学理论,可为生、熟地黄保健食品研发提供借鉴和依据。

Objective:To analyze the formula rules of raw and processed Rehmanniae Radix in traditional Chinese medicine(TCM)health food.Methods:The data of raw and processed Rehmanniae Radix health food from the State Administration for Market Regulation(SAMR)were collected,and the health care functions and TCM prescriptions were analyzed.Apriori algorithm and Kulc and imblance ratio(IR)parameters were used to analyze the formula rules in health food of raw and processed Rehmanniae Radix.Results:The raw Rehmanniae Radix health food was mainly to assist in lowering blood sugar,while the processed Rehmanniae Radix health food was mainly to enhance immunity,relieve physical fatigue,and improve nutritional anemia.Among the raw Rehmanniae Radix health food for lowering blood sugar,the main compatible TCMs were Qi-invigorating herbs,Yin-tonic herbs,relieving herbs,and antipyretic herbs,and the representative combination was raw Rehmanniae Radix-Astragali Radix-balsam pear.In processed Rehmanniae Radix health food for enhancing immunity,the main compatible TCMs were Qi-invigorating herbs,blood-tonic herbs,and Yin-tonic herbs,and the representative combination was processed Rehmanniae Radix-Codonopsis Radix-Asini Corii Colla.Among the processed Rehmanniae Radix health food for relieving physical fatigue,the main compatible TCMs were Qi-invigorating herbs,Yang-tonic herbs,and Yin-tonic herbs,and the representative combinations were processed Rehmanniae Radix-Ginseng-Epimedium and processed Rehmanniae Radix-Ginseng-Lycii Fructus.In the processed Rehmanniae Radix health food for improving nutritional anemia,the main compatible TCMs were Qi-invigorating herbs and blood-tonic herbs,and the representative combinations were processed Rehmanniae Radix-Astragali Radix-Lycii Fructus and processed Rehmanniae Radix-Astragali Radix-Angelicae Sinensis Radix.Conclusion:In health food,the application of Rehmanniae Radix follows the law of raw and processed formulas with different uses.The formulation compatibility basically conforms to the theory of TCM and modern medical theory,which can provide a reference and basis for the research and development of raw and processed Rehmanniae Radix health food.