2009—2021年成都市慢性乙型病毒性肝炎流行特征及发病趋势

Epidemiological characteristics and incidence trend of chronic viral hepatitis B in Chengdu from 2009 to 2021

目的 分析2009—2021年成都市慢性乙型病毒性肝炎流行病学特征和发病趋势,为其防治提供参考。方法 从国家法定传染病报告系统(national notifiable diseases reporting system, NNDRS)收集2009—2021年成都市慢性乙型病毒性肝炎病例数据及其年龄、性别、地区、发病月等资料,分析其流行病学特征,采用动态数列法分析其发病趋势,发病率的差异采用χ^(2)检验。结果 2009—2021年成都市累计报告慢性乙型病毒性肝炎病例45 580例,年平均发病率23.11/10万,2009年发病率最高为28.71/10万,发病率随时间变化呈下降趋势(χ^(2)_(趋势)=4 017.613,P<0.05)。男性发病率高于女性(χ^(2)=27.026,P<0.05)。60~<70岁发病率最高,为29.61/10万,0~<10岁发病率最低,为12.14/10万,不同年龄发病率差异有统计学意义(χ^(2)=49.848,P<0.05)。1月、3月发病率最高,郫都区、温江区、青白江区慢性乙型病毒性肝炎发病率分别为49.66/10万、39.28/10万、34.71/10万,不同地区发病率差异有统计学意义(χ^(2)=129.577,P<0.05)。2009—2021年成都市该病的平均发展速度为0.95,预测2022年、2023年成都市慢性乙型病毒性肝炎发病率为14.00/10万和13.30/10万。结论 2009—2021年成都市慢性乙型病毒性肝炎发病率呈下降趋势,男性、60~<70岁高发,1月和3月是发病高峰期,应强化乙肝疫苗接种、健康宣教和防治工作。

Objective To analyze the epidemiological characteristics and incidence trend of chronic viral hepatitis B in Chengdu from 2009 to 2021,and to provide reference for prevention and treatment of viral hepatitis B.Methods The data on cases of chronic viral hepatitis B in Chengdu from 2009 to 2021 were collected from the national notifiable disease reporting system(NNDRS),and the data of age,gender,region and month of onset ect.The epidemiological characteristics of chronic viral hepatitis B were analyzed,the dynamic series method was used to analyze the trend of its incidence,and the difference of incidence rate was tested analyzed by the χ^(2)test.Results A total of 45580 cases of chronic viral hepatitis B were reported in Chengdu from 2009 to 2021,with an average annual incidence of 23.11/100000.In 2009,the highest incidence of chronic viral hepatitis B was 28.71/100000.The incidence of chronic viral hepattis B showed a decreasing trend over time(χ^(2)_(trend)=4017.613,P<0.05).The incidence of male chronic viral hepatitis B was higher than that of female(χ^(2)=27.026,P<0.05).The incidence of chronic viral hepatitis B was the highest among people of 60-<70 years old(29.61/100000),and the lowest among those of 0-<10 years old(12.14/100000).There was significant difference among different age(χ^(2)=49.848,P<0.05).The incidence of chronic viral hepatitis B was highest in January and March.The incidence of chronic viral hepatitis B in Pidu,Wenjiang and Qingbaijiang Districts was as high as 49.66/100000,39.28/100000 and 34.71/100000,with significant differences in different regions(χ^(2)=129.577,P<0.05).The average development rate of chronic viral hepatitis B in Chengdu from 2009 to 2021 was 0.95,the incidence rate of chronic viral hepatitis B in Chengdu in 2022 and 2023 was predicted to be 14.00/100000 and 13.30/100000 respectively.Conclusion The infection rate of chronic viral hepatitis B shows a decreasing trend from 2009 to 2021 in Chengdu.The prevalence of chronic viral hepatitis B is high among men,people aged 60-<70 years.January and March are the peak incidence period of chronic viral hepatitis B.Vaccination,health education and prevention should be strengthened.