PRMT5在乳腺癌中的研究进展

Recent Advances of PRMT5 in Breast Cancer

蛋白精氨酸甲基转移酶5(protein arginine methyltransferase 5,PRMT5)是蛋白精氨酸甲基化转移酶家族的成员之一,是在组蛋白和非组蛋白上产生对称二甲基精氨酸的主要Ⅱ型甲基转移酶。PRMT5是一种潜在的致癌基因,参与基因转录、RNA剪切、DNA复制和DNA损伤修复等多种生物学过程,在包括乳腺癌在内的多种人类恶性肿瘤中均表达上调,将其作为新靶点进行抗乳腺癌药物研究有巨大的前景。该文通过查阅大量PRMT5和乳腺癌的相关文献,综述了PRMT5在乳腺癌中的研究进展,旨在为后续相关研究提供参考。

PRMT5(protein arginine methyltransferase 5)is a member of PRMTs(protein arginine methyltrans­ferases)family and the primary type II methyltransferase that generates symmetric-dimethyl-arginine on both histone and non-histone proteins.PRMT5 is a potential oncogene,it has been implicated in the control of many cellular processes such as gene transcription,RNA splicing,DNA replication and DNA damage response.It is overexpressed in numerous human cancers,including breast cancer.Therefore,it has great prospect to be used as a new target for anti-breast cancer drug research.This paper reviews the recent advances of PRMT5 in breast cancer by consulting a large number of rel­evant literatures on PRMT5 and breast cancer,aiming to provide a reference for subsequent relevant research.