食管支架置入联合化疗治疗中晚期食管癌的效果

Effect of esophageal stenting combined with chemotherapy on patients with advanced esophageal cancer

目的 探讨食管支架置入联合化疗治疗中晚期食管癌患者的效果。方法 选取2021年2月至2022年6月河南科技大学第一附属医院收治的86例食管癌患者为研究对象,根据治疗方法分为研究组(n=40)与对照组(n=46)。研究组采用食管支架置入联合化疗,对照组采用单纯化疗,比较两组气促指数和营养评分、吞咽困难改善情况、治疗前后肿瘤相关指标[癌胚抗原(CEA)和糖类抗原199(CA199)]、治疗前后生活质量(KPS评分)、术后1年预后情况。结果 治疗后,研究组气促指数和营养评分均优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后研究组吞咽困难改善情况优于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组CEA、CA199比较,差异未见统计学意义(P>0.05);治疗后两组CEA、CA199与本组治疗前比较均降低,且研究组低于对照组,组间、组内比较差异有统计学意义(P<0.05)。治疗前两组KPS评分比较,差异未见统计学意义(P>0.05);治疗后两组KPS评分与本组治疗前比较均升高,且研究组高于对照组,组间、组内比较差异有统计学意义(P<0.05)。术后1年,两组总生存率比较,差异未见统计学意义(P>0.05)。结论 食管支架置入联合化疗对中晚期食管癌患者的疗效更佳,可改善患者的气促、营养状态,提高生活质量,不影响化疗的疗效及预后。

Objective To investigate the efficacy of esophageal stenting combined with chemotherapy on patients with advanced esophageal cancer.Methods Eighty-six esophageal cancer patients admitted to the First Affiliated Hospital of Henan University of Science and Technology from February 2021 to June 2022 were selected as the research subjects.They were divided into study group(n=40)and control group(n=46)based on treatment methods.The study group used stent implantation combined with chemotherapy,while the control group used simple chemotherapy.The two groups were compared in terms of shortness of breath index and nutritional score,improvement of swallowing difficulty,tumor related indicators before and after treatment[carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)],quality of life before and after treatment(KPS score),and 1-year postoperative prognosis Results The study group had better shortness of breath index and nutritional score than the control group,and the differences between the two groups were significant(P<0.05).After treatment,the improvement of swallowing difficulty in the study group was better than that in the control group,and the difference between the two groups was significant(P<0.05).Before treatment,there was no significant difference in CEA and CA199 between the two groups(P>0.05).After treatment,the levels of CEA and CA199 in both groups were lower than those before treatment,and those in the study group were lower than those in the control group.There were significant differences between and within groups(P<0.05).Before treatment,there was no significant difference in KPS scores between the two groups(P>0.05).After treatment,the KPS scores of both groups were higher than those before treatment,and those in the study group were higher than those in the control group.There were significant differences between and within groups(P<0.05).One year after surgery,there was no significant diference in overall survival rate between the two groups(P>0.05).Conclusions Esophageal stent implantation combined with chemotherapy has better therapeutic effect on patients with advanced esophageal cancer,which can improve their shortness of breath and nutritional status,improve their quality of life,without affecting the efficacy and prognosis of chemotherapy.