基于数据挖掘研究黄飞翔治疗心悸用药规律

Study on Medication Rules of HUANG Feixiang in Treating Palpitations Based on Data Mining

目的:基于中医传承辅助平台(V2.5)研究黄飞翔主任医师诊治心悸的用药规律。方法:收集符合纳入标准及排除标准的黄飞翔主任医师治疗心悸的门诊病例处方,借助中医传承辅助平台(V2.5),通过频数分析、关联规则、复杂熵层次聚类分析等高级数据挖掘方法,进行用药规律分析。结果:共收录病例106例,包含215首处方,涉及86味中药,共2 440味次。频次≥34次的药物排前10位依次为炙甘草、陈皮、生地黄、枳壳、龙骨、牡蛎、川芎、丹参、党参、茯苓。中药四气以寒性、温性、平性为主;五味以甘、苦、辛为主;归经多入肝、心、脾经。高频药物中功效分类排前5位依次为安神、化痰祛湿、补气、活血化瘀、疏肝理气类。基于关联规则分析获得12组高频药物组合,排前3位依次为龙骨-牡蛎、炙甘草-生地黄、丹参-党参。基于复杂熵层次聚类分析挖掘出新处方4首。结论:黄飞翔主任医师治疗心悸擅用安养心神、清热化痰、疏肝解郁、益气养心、活血化瘀类药物。

Objective:Based on the Chinese Medicine Inheritance Assistance Platform(V2.5),this paper studies the medication rules of Chief Physician HUANG Feixiang in the diagnosis and treatment of palpitations.Methods:The outpatient prescriptions by HUANG for the treatment of palpitations,which met the inclusion criteria and exclusion criteria,were collected.With the help of Chinese Medicine Inheritance Assistance Platform(V2.5)and advanced data mining methods such as frequency analysis,association rules and complex entropy hierarchical clustering analysis,the medication rules was analyzed.Results:A total of 106 cases were involved,including 215 prescriptions and 86 Chinese herbs,with a total of 2440 using times.The top 10 herbs with frequency equal to or over 34 times were Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Citri Reticulatae Pericarpium,Rehmanniae Radix,Aurantii Fructus,Os Draconis,Ostreae Concha,Chuanxiong Rhizoma,Salviae Miltiorrhizae Radix et Rhizoma,Codonopsis Radix and Poria.The four qi of the used Chinese herbs were mainly cold,warm and balanced;the five flavours were mainly sweet,bitter and acrid and the channel entered into the liver,heart,spleen.The effect of the top five herbs were calming the mind,dissolving phlegm and dispelling dampness,supplementing qi,invigorating blood and dissolving stasis,and soothing the liver and rectifying qi.Based on association rule analysis,twelve groups of high-frequency herbal combinations were obtained,and the top three were Os Draconis-Ostreae Concha,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle-Rehmanniae Radix,and Salviae Miltiorrhizae Radix et Rhizoma-Codonopsis Radix.Four new prescriptions were excavated based on entropy cluster analysis.Conclusion:HUANG is good at treating palpitations with herbs whose effects includes calming and nourishing the heart spirit,clearing heat and dissolving phlegm,soothing the liver and resolving constraint,boosting qi and nourishing the heart,and invigorating blood and dissolving stasis.