半夏白术天麻汤联合针刺治疗缺血性脑血管病康复期患者临床研究

Clinical Study on Banxia Baizhu Tianma Decoction Combined with Acupuncture for Patients with Ischemic Cerebrovascular Disease During Convalescence

目的:观察半夏白术天麻汤联合针刺治疗缺血性脑血管病康复期患者临床疗效。方法:选取83例缺血性脑血管病康复期患者,按随机数字表法分为对照组40例和治疗组43例。对照组采用针刺治疗,治疗组采用半夏白术天麻汤联合针刺治疗。比较2组临床疗效,以及治疗前后炎症因子[白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、超敏C-反应蛋白(hs-CRP)]水平、血液流变学指标、简易智力状态检查量表(MMSE)评分、美国国立卫生院神经功能缺损量表(NIHSS)评分变化。结果:治疗组总有效率为93.0%,对照组为82.5%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清IL-6、TNF-α、hs-CRP水平均较治疗前降低(P<0.05),且治疗组IL-6、TNF-α、hs-CRP水平均低于对照组(P<0.05)。治疗后,2组全血低切黏度、血浆黏度、全血高切黏度均较治疗前降低(P<0.05),且治疗组全血低切黏度、血浆黏度、全血高切黏度均低于对照组(P<0.05)。治疗后,2组MMSE评分均较治疗前升高(P<0.05),NIHSS评分均较治疗前降低(P<0.05);且治疗组MMSE评分高于对照组(P<0.05),NIHSS评分低于对照组(P<0.05)。结论:半夏白术天麻汤联合针刺治疗缺血性脑血管病康复期患者,能够进一步提高临床疗效,减轻机体炎症反应及神经功能损伤,有效改善患者认知功能及血液流变学状态。

Objective:To observe the clinical effect of Banxia Baizhu Tianma Decoction combined with acupuncture for patients with ischemic cerebrovascular disease during convalescence.Methods:A total of 83 cases of patients with ischemic cerebrovascular disease during convalescence were selected and divided into the control group and the treatment group according to the random number table method,with 40 and 43 cases in each group respectively.The control group was treated with acupuncture,and the treatment group was treated with Banxia Baizhu Tianma Decoction combined with acupuncture.The changes in levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],hemorheology indexes,Mini-mental State Examination(MMSE)scores,and National Institutes of Health Stroke Scale(NIHSS)scores before and after treatment as well as the clinical effects were compared between the two groups.Results:The total effective rate was 93.0%in the treatment group and 82.5%in the control group,the difference being significant(P<0.05).After treatment,the levels of IL-6,TNF-α,and hs-CRP in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-6,TNF-α,and hs-CRP in the treatment group were lower than those in the control group(P<0.05).After treatment,whole blood low-shear viscosity,plasma viscosity,and whole blood high-shear viscosity in the two groups were decreased when compared with those before treatment(P<0.05),and whole blood low-shear viscosity,plasma viscosity,and whole blood high-shear viscosity in the treatment group were lower than those in the control group(P<0.05).After treatment,MMSE scores were increased when compared with those before treatment(P<0.05),and NIHSS scores were decreased when compared with those before treatment(P<0.05);MMSE score in the treatment group was higher than that in the control group(P<0.05),and NIHSS score was lower than that in the control group(P<0.05).Conclusion:Banxia Baizhu Tianma Decoction combined with acupuncture for patients with ischemic cerebrovascular disease during convalescence can further improve clinical effect,reduce inflammation and neurological defects,and effectively improve the cognitive function and hemorheological state of patients.