抗敏镇咳方治疗咳嗽变异性哮喘风邪恋肺证临床研究

Clinical Study on Kangmin Zhenke Prescription for Cough Variant Asthma with Wind Pathogen Adhering Lung Syndrome

目的:观察抗敏镇咳方治疗咳嗽变异性哮喘(CVA)风邪恋肺证的临床效果。方法:将68例CVA风邪恋肺证患者随机分为对照组和观察组各34例,对照组服用孟鲁司特钠片治疗,观察组予抗敏镇咳方治疗,2组疗程均为2周。治疗前后分别应用视觉模拟评分法(VAS)进行咳嗽评分,检测肺功能参数[第1秒用力呼气量(FEV1)、第1秒用力呼气量占用力肺活量的百分比(FEV1/FVC)、剩余肺活量50%时的呼气流速(MEF50)、剩余肺活量25%时的呼气流速(MEF25)],血清P物质(SP)和肺泡灌洗液SP水平。结果:治疗后,2组日间咳嗽积分、夜间咳嗽积分与治疗前比较均下降(P<0.05)。观察组日间咳嗽积分、夜间咳嗽积分均低于对照组(P<0.05)。观察组FEV1、FEV1/FVC及MEF50值、MEF25值均高于治疗前(P<0.05),对照组FEV1、MEF50值、MEF25值均高于治疗前(P<0.05);观察组4项指标值均高于对照组(P<0.05)。2组血清SP、肺泡灌洗液SP水平均较治疗前下降(P<0.05)。观察组血清SP、肺泡灌洗液SP水平均低于对照组(P<0.05)。结论:抗敏镇咳方能够有效缓解CVA风邪恋肺证患者的咳嗽症状,改善肺功能,可能与减轻气道炎症、降低气道高反应性有关。

Objective:To observe the clinical effect of Kangmin Zhenke Prescription for cough variant asthma(CVA)with wind pathogen adhering lung syndrome.Methods:A total of 68 cases of CVA patients with wind pathogen adhering lung syndrome were randomly divided into the control group and the observation group,with 34 cases in each group.The control group was treated with Montelukast Sodium Tablets,and the observation group was treated with Kangmin Zhenke Prescription.Both groups were treated for 2 weeks.Before and after treatment,Visual Analogue Scale(VAS)was applied to score the cough scores,to detect the indexes of lung function including forced expiratory volume in one second(FEV 1),ratio of forced expiratory volume in one second to forced vital capacity(FEV 1/FVC),maximal expiratory flow at 50%of the forced vital capacity(MEF50),and maximal expiratory flow at 25%of the forced vital capacity(MEF25),and to detect the levels of substance P(SP)in serum and bronchoalveolar lavage fluid.Results:After treatment,the scores of cough during daytime and at night in the two groups were decreased when compared with those before treatment(P<0.05).The scores of cough during daytime and at night in the observation group were lower than those in the control group(P<0.05).The values of FEV 1,FEV 1/FVC,MEF50,and MEF25 in the observation group were higher than those before treatment(P<0.05),the values of FEV 1,MEF50,and MEF25 in the control group were higher than those before treatment(P<0.05),and the four values in the observation group were higher than those in the control group(P<0.05).The SP levels in serum and bronchoalveolar lavage fluid in the two groups were decreased when compared with those before treatment(P<0.05),and the SP levels in serum and bronchoalveolar lavage fluid in the observation group were lower than those in the control group(P<0.05).Conclusion:Kangmin Zhenke Prescription can effectively relieve cough in CVA patients with wind pathogen adhering lung syndrome,and improve their lung function,which may be related to reducing airway inflammation and reducing airway hyperresponsiveness.