摘要
目的探讨抵抗素与多发性骨髓瘤(MM)发生风险之间是否存在因果关系。方法采用两样本孟德尔随机化分析方法,将抵抗素相关遗传变异数据作为工具变量,使用MM的全基因组关联研究数据作为结局事件,采用逆方差加权法(IVW)、MR-Egger、加权中位数、加权模式和简单模式5种方法分析抵抗素对MM发生风险的因果影响。结果5种分析方法均显示抵抗素与MM之间不存在因果关系(P>0.05)。敏感性分析显示,结果稳健,基因无水平多效性、异质性及离群值,无单独的SNPs影响结果。结论本研究不支持抵抗素与MM发生风险存在因果关系。
Objective To investigate the causal relationship between resistin and multiple myeloma(MM).Methods A two-sample Mendelian randomization analysis was conducted using genetic variants(SNPs)associated with resistin as instrumental variables and MM genome-wide association study(GWAS)data as the outcome event.Five analysis methods,including inverse-variance weighted(IVW),MR-Egger,weighted median,weighted model,and simple model were used to assess the causal impact of resistin on the risk of MM.Results None of the five analysis methods showed a causal relationship between resistin and multiple myeloma(P>0.05).Sensitivity analysis indicated consistent and robust results,with no evidence of horizontal pleiotropy,heterogeneity,outliers,or individual SNPs influencing the findings.Conclusion This Mendelian randomization study provides no support for a causal relationship between resistin and the risk of multiple myeloma.
作者
王洪波
王秀娟
郭新红
江明
WANG Hongbo;WANG Xiujuan;GUO Xinhong;JIANG Ming(Hematologic Disease Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,P.R.China;Institute of Hematology of Xinjiang Uygur Autonomous Region,Urumqi 830054,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2023年第9期1005-1010,共6页
Chinese Journal of Evidence-based Medicine
基金
新疆维吾尔自治区自然科学基金项目(编号:2021D01C333)。
关键词
孟德尔随机化
多发性骨髓瘤
抵抗素
Mendelian randomization study
Multiple myeloma
Resistin
