临床实践指南透明度评价工具2.0的循证构建

Evidence-based construction of transparency evaluation tool 2.0 of clinical practice guidelines

目的以公信力为导向,构建临床实践指南(CPGs)透明度评价工具2.0。方法采用德尔菲法对评价指标的重要性和可操作性进行评分和筛选,并利用层次分析法确定指标权重,通过专家共识会议确定最终评价指标体系。结果构建了包括利益冲突和制订流程2个一级指标,制订人员、评审人员、计划书与注册、证据生产、推荐意见形成、外部评审6个二级指标,并在二级指标的基础上,从披露和管理的角度出发构建了21个三级指标,其逻辑结构严谨、和谐。结论本研究构建的CPGs透明度评价工具2.0,为CPGs的透明度评价提供了新的衡量标准和评估体系。

Objective To develop a transparency evaluation tool 2.0 of clinical practice guidelines(CPGs)oriented by public trust.Methods The Delphi method was employed to score and select the importance and operability of evaluation indicators.The analytic hierarchy process was used to determine the weights of the indicators.And the final evaluation indicator system was determined through expert consensus meeting.Results It constructed two first-level indicators including conflict of interest and formulation process,and six second-level indicators,including guideline developers,reviewers,protocol and registration,evidence production,recommendation formation,and external review.Based on the second-level indicators,a total of 21 third-level indicators were constructed from the perspectives of disclosure and management.The logical structure of the tool is rigorous and harmonious.Conclusion The CPGs transparency assessment tool 2.0 developed in this study provides measurement standards and an evaluation framework for assessing transparency in CPGs.