早年创伤事件和端粒长度与抑郁症关系的研究进展

Advances in the relationship between early traumatic events and telomere length and depression

抑郁症是严重精神疾病的一种,其机制涉及心理-生理-社会多方面,早年创伤事件导致的早年生活压力是抑郁症的主要风险因素。有研究表明抑郁症患者存在端粒缩短现象,端粒长度缩短可能与抑郁症的发生有关,特别是遭受早年创伤事件也与端粒缩短有关。现阐述早年创伤事件和端粒长度与抑郁症的关系,以及早年创伤事件影响端粒长度的相关机制,探究其中相关的病理机制,为抑郁症防治提供重要的临床参考意义。

Depressive disorder is one of the serious mental diseases,and its mechanism involves psychological,physiological and social aspects.Early life stress caused by traumatic events is a major risk factor for depression.Studies have shown that patients with depression exhibit telomere shortening,which may be related to the occurrence of depression,especially with exposure to early traumatic events.This paper describes the relationship between early traumatic events and telomere length and depression,and reviews the related mechanisms of early traumatic events affecting telomere length,so as to explore the genetic and pathological mechanisms related to the two,and provide important clinical reference significance for the prevention and treatment of depression.