中链甘油三酯生酮饮食治疗难治性癫痫的研究进展

Advances in medium-chain triglyceride ketogenic diet for refractory epilepsy

生酮饮食(Ketogenic diet,KD)是治疗难治性癫痫(Refractory epilepsy,RE)有效的治疗方法之一,在抗癫痫发作药物(Anti-seizure medications,ASMs)无效或疗效欠佳、无法手术或手术无效时,均推荐使用KD。生酮饮食中中链甘油三酯(Medium-chain triglyceride,MCT)生酮饮食的疗效与经典生酮饮食(Classic ketogenic diet,CKD)一样好,这已经在几项回顾性、前瞻性和随机研究中得到了证实,而且MCT比长链甘油三酯更能生酮,因此,中链甘油三酯饮食(Medium-chain triglyceride diet,MCTD)允许更多的碳水化合物和蛋白质食物,这使得MCTD比CKD更美味。现就MCTD治疗难治性癫痫的相关机制及临床疗效方面的研究进展进行综述。

Ketogenic diet(KD)is one of the effective treatments for refractory epilepsy(RE)and is recommended when anti-seizure medications(ASMs)are ineffective or less effective,inoperable or ineffective.The efficacy of the medium-chain triglyceride(MCT)ketogenic diet is as good as the classical KD(CKD),which has been demonstrated in several retrospective,prospective,and randomized studies,and MCT is more ketogenic than long-chain triglycerides,so MCTD allows more carbohydrate and protein foods,which makes MCTD more palatable than CKD more palatable.Research advances in the mechanisms and clinical efficacy associated with MCTD in the treatment of refractory epilepsy are reviewed.