cenobamate在癫痫治疗中的研究进展

Research progress of cenobamate in the treatment of epilepsy

cenobamate是一种新型抗癫痫发作药物(Antiseizure medication,ASMs),用于治疗成人局灶性癫痫发作。cenobamate有独特的药理学特征,具有双重作用机制,包括通过阻断持续的钠电流增强电压门控钠通道的灭活状态,以及在非苯二氮卓结合位点上对γ-氨基丁酸(γ-aminobutyric acid,GABA)A受体的正性变构调节。研究显示,cenobamate是局灶性癫痫的有效治疗方法,表现在能显著降低癫痫发作频率、高应答率和较高的癫痫无发作率,且耐受性和安全性好。本文就cenobamate作为一种新型ASMs的作用机制、药代动力学特征、临床疗效、安全性等方面进行综述。

Cenobamate is one of the latest antiseizure medications(ASMs)developed for the treatment of focal onset seizures in adult patients.Cenobamate is characterized by a peculiar pharmacology.The mechanisms responsible for its anti-seizure activity include enhancement of the inactivated state of voltage-gated sodium channels with blockade of the persistent sodium current and positive allosteric modulation of GABAa receptors at a non-benzodiazepine binding site.Studies showed that cenobamate appears to be an effective treatment for focal epilepsy,showing reductions in seizure frequency,increased responder rates,and high rates of seizure freedom,and is well tolerated and safe.This article reviews the mechanism,pharmacokinetic characteristics,clinical efficacy,and safety of cenobamate as a novel anti-seizure drug.