粪菌移植在结直肠癌治疗中的研究进展及应用前景

Research progress and application prospects of fecal microbiota transplantation in colorectal cancer treatment

结直肠癌(colorectal cancer,CRC)是消化系统常见的恶性肿瘤。近年来,人们发现肠道菌群改变通过各种复杂的机制影响CRC的发生、发展。粪菌移植(fecal microbiota transplantation,FMT)作为一种重建肠道菌群的新技术,通过将健康供体的肠道菌群移植到患者肠道中,可以达到重新调节肠道菌群平衡的目的。本文对肠道菌群影响CRC的机制以及FMT在CRC治疗中的研究进展及应用前景进行综述,特别是对FMT在减轻CRC治疗引起的不良反应、影响CRC患者抗癌治疗的效果,以及CRC预防中的潜力等方面进行总结。

Colorectal cancer(CRC)is a common malignant tumor of the gastrointestinal system,and recently,it has been found that gut microbiota changes affect the development of CRC through various complex mechanisms.Fecal microbiota transplantation(FMT)is a new technique to rebalance the gut microbiota by transplanting gut microbiota from a healthy donor into the patient's intestine.In this paper,we review the mechanism of gut microbiota affecting CRC and the research progress and application prospects of FMT in CRC treatment,especially the potential of FMT in reducing the adverse effects caused by CRC treatment,influencing the effect of anti-cancer treatment in CRC patients,and the potential of CRC prevention.