一次性根治术对小儿肛瘘创面生长因子水平的影响

The effect of one-time radical surgery on growth factor levels in pediatric anal fistula wounds

目的探讨一次性根治术对小儿肛瘘创面生长因子水平的影响。方法选取2018年9月至2020年9月本院收治的80例肛瘘患儿作为研究对象,随机分为观察组与对照组,每组40例。对照组采用常规切开挂线治疗,观察组采用一次性根治术治疗,比较两组围手术期指标、并发症发生率、复发率及治疗前后创面生长因子水平。结果观察组手术时间、伤口愈合时间、住院时间均短于对照组,术中出血量少于对照组,愈合瘢痕面积小于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率及复发率均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组创面表皮生长因子、血管内皮细胞生长因子及纤维细胞生长因子-1水平比较差异无统计学意义;治疗后,两组创面表皮生长因子、血管内皮细胞生长因子、纤维细胞生长因子-1水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论一次性根治术治疗小儿肛瘘能缩短治愈时间,改善肛门功能,缓解临床指标,降低术后复发率,减少术后并发症发生,改善患儿预后,值得临床推广应用。

Objective To explore the effect of one-time radical surgery on growth factor levels in pediatric anal fistula wounds.Methods 80 children with anal dysfunction admitted to our hospital from September 2018 to September 2020 were selected as the research subjects and they were randomly divided into the observation group and the control group,with 40 cases in each group.The control group received routine incision and thread hanging treatment,while the observation group received one-time radical surgery,the perioperative indicators,incidence of complications,recurrence rate,and wound growth factor levels before and after treatment were compared between the two groups.Results The operation time,wound healing time and hospitalization time in the observation group were shorter than those in the control group,the intraoperative blood loss was less than that in the control group,and the healing scar area was smaller than that in the control group,the differences were statistically significant(P<0.05).The incidence of complications and recurrence rate in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of epidermal growth factor,vascular endothelial growth factor and fibroblast growth factor-1 between the two groups;after treatment,the levels of epidermal growth factor,vascular endothelial growth factor and fibroblast growth factor-1 of the two groups were higher than those before treatment,and the observation group were higher than the control group,the differences were statistically significant(P<0.05).Conclusion The one-time radical surgery for pediatric anal fistula can shorten the cure time,improve anal function,alleviate clinical indicators,reduce postoperative recurrence rate,reduce postoperative complications,and improve patient prognosis,which is worthy of clinical promotion and application.