肺动脉高压神经调控机制研究进展

Advances in neuromodulation of pulmonary hypertension

肺动脉高压是一种以肺血管阻力增加、肺血管系统的不良性重塑为特征,导致右心肥厚并最终因右心衰而死亡的进行性疾病。其准确发病机制尚未完全明确,在众多机制中,自主神经功能紊乱也是促成肺动脉高压的因素之一。在肺动脉高压中,交感神经过度激活是公认的一种假说,肺动脉去神经术治疗肺动脉高压取得了一定的疗效。本文对肺血管的神经解剖基础、神经调控参与的肺动脉高压发生发展的可能机制及神经调控在肺动脉高压治疗中的应用进行系统性综述。

Pulmonary hypertension is a progressive disease characterized by an increase in pulmonary vascular resistance,leading to unfavorable pulmonary vascular remodeling.This condition eventually leads to right ventricular hypertrophy and ultimately death from right ventricular failure.Although the exact pathogenesis of pulmonary hypertension remains unclear,autonomic nervous system dysfunction is recognized as one of the contributing factors.Increasing evidence supports the hypothesis that activation of the sympathetic nervous system plays a role in the development of pulmonary hypertension.In addition,pulmonary artery denervation has shown some effectiveness in the treatment of this condition.This article provides a comprehensive review of the neuroanatomical basis of the pulmonary vessels,the potential mechanisms underlying the onset and progression of pulmonary hypertension in relation to neuromodulation,and the application of neuromodulation techniques in its treatment.