摘要
Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment that occurs in old age and pre-old age[1].Apolipoprotein4(ApoE4)is the most important genetic risk factor for late-onset AD[2].Peripheral apoE4 is separated from that in the CNS by the blood-brain barrier(BBB)and is abundantly produced by the liver and macrophages and released into the blood to modulate lipid-related events.
基金
supported by the Science and Technology Innovation 2030 Major Projects(2022ZD0211600)
the National Natural Science Foundation of China(82271574,82071204,81871069)
the Key Projects of Commission of Health,Jiangsu Province(ZDB2020008).
