从多发性硬化神经损伤机制新进展看无疾病活动证据治疗目标的演变

Evolution of no evidence of disease activity therapeutic goals of multiple sclerosis from new progress of nerve injury mechanisms

多发性硬化是一种主要累及中枢神经系统的严重自身免疫性炎性疾病。近年来,多发性硬化神经损伤机制的探索不断深入。作用于不同靶点的疾病修正治疗药物亦不断涌现。对多发性硬化神经损伤机制认识的加深有助于临床医生更全面理解疾病修正治疗目标的演进。文中就多发性硬化的神经损伤机制及其与疾病修正治疗目标的关系作一综述。

Multiple sclerosis is a severe autoimmune inflammatory disease mainly involving the central nervous system.In recent years,the exploration of the mechanism of nerve injury in multiple sclerosis has made great progress.At the same time,disease-modifying therapeutic drugs with different targets are also emerging.Understanding of the mechanisms of nerve injury in multiple sclerosis can help clinicians comprehensively understand the evolution of disease-modifying therapeutic targets of this disorder.Here,the mechanisms of nerve injury in multiple sclerosis and the relationship with the evolution of disease-modifying therapeutic targets are reviewed.