晚期早产儿低血糖危险因素分析

Risk factors of hypoglycemia in late preterm infants

目的探讨晚期早产儿发生低血糖的危险因素。方法选择2019年1月至2021年12月厦门市妇幼保健院新生儿重症监护病房收治的晚期早产儿进行回顾性研究,发生低血糖的患儿纳入低血糖组,采用系统随机抽样法,按1∶1的比例选取同期血糖正常患儿为对照组。比较两组患儿围产期及母亲妊娠期情况。采用单因素分析及多因素logistic回归分析筛选晚期早产儿发生低血糖的危险因素。结果低血糖组和对照组各纳入366例,两组早产儿出生体重差异无统计学意义(P>0.05)。多因素logistic回归分析显示,产前糖皮质激素治疗(OR=1.567,95%CI 1.127~2.180)、剖宫产(OR=2.013,95%CI 1.376~2.944)、双胎妊娠(OR=2.241,95%CI 1.479~3.396)、母亲妊娠期糖尿病(OR=1.635,95%CI 1.131~2.365)是晚期早产儿发生低血糖的独立危险因素(P<0.05)。结论产前应用糖皮质激素治疗、剖宫产、双胎妊娠和母亲妊娠期糖尿病是晚期早产儿发生低血糖的独立危险因素。

Objective To study the risk factors of hypoglycemia in late preterm infants.Methods From January 2019 to December 2021,late premature infants admitted to NICU of our hospital were retrospectively studied.The infants with hypoglycemia were assigned into the hypoglycemia group and infants with same gestational age and normoglycemia were assigned into the control group in a 1∶1 ratio.The perinatal and maternal data of the two groups were compared.Multivariate logistic regression analysis was used to determine the risk factors of hypoglycemia in late premature infants.Results A total of 366 cases each were included in the hypoglycemia group and the control group.No significant difference existed in birth weight between the two groups(P>0.05).Multivariate logistic regression analysis showed that antenatal corticosteroid(OR=1.567,95%CI 1.127-2.180),cesarean section(OR=2.013,95%CI 1.376-2.944),twin birth(OR=2.241,95%CI 1.479-3.396)and infant of a diabetic mother(OR=1.635,95%CI 1.131-2.365)were the risk factors of hypoglycemia in late preterm infants(P<0.05).Conclusions Antenatal corticosteroid,cesarean section,twin birth and infant of a diabetic mother are independent risk factors for hypoglycemia in late preterm infants.