甲状腺全切术治疗分化型甲状腺癌的效果

The Effect of Total Thyroidectomy in the Treatment of Differentiated Thyroid Cancer

目的:分析甲状腺全切治疗分化型甲状腺癌的效果。方法:回顾性分析2022年1—12月鄂州市第三医院收治的分化型甲状腺癌共70例患者的临床资料,结合不同治疗方式分成对照组(甲状腺近全切)32例和观察组(甲状腺全切)38例,统计并对比两组有效率;手术指标;治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)及半乳糖凝集素-3(Gal-3)水平;并发症发生率。结果:观察组有效率高于对照组,差异有统计学意义(P<0.05)。两组术中失血量、手术时长及住院时长相比差异均无统计学意义(P>0.05)。术前,两组TNF-α、IL-6、VEGF、Gal-3水平相比差异均无统计学意义(P>0.05);术后,两组TNF-α、IL-6、VEGF、Gal-3水平均较术前降低(P<0.05),且观察组各项指标均低于对照组,差异均有统计学意义(P<0.05)。两组皮下积液、皮下气肿、喉返神经受损和淋巴瘘等并发症发生率相比差异无统计学意义(P>0.05)。结论:甲状腺全切用于分化型甲状腺癌的疗效较为理想,能降低血清中的TNF-α、IL-6、VEGF、Gal-3水平,值得采用。

Objective:To analyze the effectiveness of total thyroidectomy in the treatment of differentiated thyroid cancer.Method:Clinical data about 70 patients with differentiated thyroid cancer admitted to Ezhou Third Hospital from January to December 2022 was retrospectively analyzed.According to different therapies,patients were assigned to control group(n=32,near-total thyroidectomy)and observation group(n=38,total thyroidectomy).The effective surgical rates,operation indexes,TNF-α,IL-6,VEGF,Gal-3 levels and surgical complications between the two groups were calculated and compared.Result:The effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The intraoperative bleeding volume,operation time and hospital stays between the two groups were not significantly different(P>0.05).Before surgery,TNF-α,IL-6,VEGF and Gal-3 levels between the two groups were not significantly different(P>0.05);after surgery,TNF-α,IL-6,VEGF and Gal-3 levels of the two groups were significantly lower than those before surgery(P<0.05);all indicators in the observation group were lower than those in the control group(P<0.05).The incidence of subcutaneous hydrops,subcutaneous emphysema,recurrent laryngeal nerve injury and lymphatic leakage between the two groups was not significantly different(P>0.05).Conclusion:The therapeutic effect of total thyroidectomy for differentiated thyroid cancer is ideal,as it can reduce the serum TNF-α,IL-6,VEGF and Gal-3 levels.It is worthy of clinical application.