帕瑞昔布钠对腰椎间盘突出症患者疼痛介质及生存质量的影响

Influence of Parecoxib Sodium on Pain Mediators and Life Quality of Patients with Lumbar Disc Herniation

目的:探究帕瑞昔布钠对腰椎间盘突出症患者疼痛介质及生存质量的影响。方法:将2020年3月—2022年12月上海市东方医院吉安医院的120例腰椎间盘突出症患者根据随机数字表法分为对照组60例和观察组60例。对照组进行常规术后镇痛,观察组则在对照组的基础上于术后应用帕瑞昔布钠。比较两组不良反应总发生率、手术前后疼痛评分[视觉模拟评分法(VAS)]、疼痛介质指标[血清P物质(SP)、前列腺素E2(PGE2)、5-羟色胺(5-HT)及神经肽Y(NPY)]及生存质量[世界卫生组织生存质量测定量表(WHOQOL-100)]。结果:两组不良反应总发生率比较,差异无统计学意义(P>0.05),术前两组VAS评分结果构成、疼痛介质指标及WHOQOL-100各领域评分比较,差异均无统计学意义(P>0.05),术后6、12及24 h观察组VAS评分结果构成均优于对照组,观察组疼痛介质指标均显著低于对照组,术后1周观察组的WHOQOL-100各领域评分均显著高于对照组,差异均有统计学意义(P<0.05)。结论:帕瑞昔布钠有助于控制腰椎间盘突出症患者疼痛介质表达及改善其生存质量,在腰椎间盘突出症患者中的应用效果值得肯定。

Objective:To investigate the influence of Parecoxib Sodium on pain mediators and life quality of patients with lumbar disc herniation.Method:A total of 120 patients with lumbar disc herniation in Shanghai East Hospital Ji’an Hospital from March 2020 to December 2022 were divided into the control group with 60 cases and the observation group with 60 cases by the random number table method.The control group was treated with routine postoperative analgesia,and the observation group was treated with Parecoxib Sodium on the basis of the control group.The total adverse reaction rate,preoperative and postoperative pain scores[visual analogue scale(VAS)],the pain mediators[serum substance P(SP),prostaglandin E2(PGE2),5-hydroxytryptamine(5-HT)and neuropeptide Y(NPY)]and quality of life[World Health Organization quality of life scale(WHOQOL-100)]of two groups were compared.Result:There was no significant difference in the incidence of the total adverse reactions between the two groups(P>0.05).The composition of VAS scoring results,pain mediators and WHOQOL-100 scores in every field of two groups before the operation were compared,the differences were not statistically significant(P>0.05).At 6,12 and 24 h after the operation,the composition of VAS scoring results in the observation group were better than those in the control group,and the pain mediators of the observation group were significantly lower than those of the control group,the WHOQOL-100 scores in every field at 1 week after the operation were significantly higher than those of the control group,the differences were all statistically significant(P<0.05).Conclusion:The Parecoxib Sodium can effectively control the pain mediators and improve the life quality of patients with lumbar disc herniation,its application effect in the patients with lumbar disc herniation is worthy of recognition.