补中益气汤联合放化疗对肺癌术后患者免疫功能及生活质量的影响

Effect of Buzhong Yiqi Decoction Combined with Chemoradiotherapy on Immune Function and Quality of Life in Postoperative Patients with Lung Cancer

目的:探讨肺癌术后患者应用补中益气汤联合放化疗的效果。方法:采用随机数字表法将2020年4月—2022年4月江西中医药大学附属医院收治88例肺癌术后患者分为两组,各44例。对照组予以放化疗,观察组予以放化疗+补中益气汤。放疗结束后,比较两组中医症候积分、免疫功能、生活质量及毒副反应。结果:放疗结束后,观察组中医症候积分均较对照组低,CD4^(+)、CD4^(+)/CD8^(+)及癌症患者生命质量测定量表(FACT-G)各维度评分均较对照组高,CD8^(+)及胃肠道不良反应、骨髓抑制发生率均较对照组低,差异均有统计学意义(P<0.05)。结论:肺癌术后患者应用补中益气汤联合放化疗可改善临床症状,增强机体免疫力,提高患者生活质量,且有助于减轻放化疗毒副反应,值得推广。

Objective:To investigate the effect of Buzhong Yiqi Decoction combined with chemoradiotherapy in postoperative patients with lung cancer.Method:A total of 88 lung cancer postoperative patients admitted to Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from April 2020 to April 2022 were divided into two groups by random number table method,with 44 cases in each group.The control group was treated with chemoradiotherapy,while the observation group was treated with chemoradiotherapy plus Buzhong Yiqi Decoction.After radiotherapy, the TCM syndrome score, immune function, quality of life and side effects were compared between the two groups. Result: After radiotherapy, the scores of TCM syndrome in the observation group were lower than those in the control group, the levels of CD4^(+), CD4^(+)/CD8^(+) and the scores of dimensions of functional assessment of cancer therapy-G (FACT-G) for cancer patients were higher than those in the control group, and the level of CD8^(+), the incidences of gastrointestinal adverse reactions and myelosuppression were lower than those in the control group, with statistical differences (P<0.05). Conclusion: Buzhong Yiqi Decoction combined with chemoradiotherapy can improve the clinical symptoms, enhance the body immunity, improve the quality of life of patients, and help to reduce the side effects of chemoradiotherapy, which is worthy of promotion.