益气宣肺汤加减联合布地奈德对慢性阻塞性肺疾病稳定期患者免疫功能及肺功能的影响

Effect of Modified Yiqi Xuanfei Decoction Combined with Budesonide on Immune Function and Lung Function of Patients with Stable Phase of Chronic Obstructive Pulmonary Disease

目的:分析益气宣肺汤加减联合布地奈德在慢性阻塞性肺疾病稳定期患者中的治疗效果。方法:选取2021年4月—2023年4月安顺市西秀区人民医院收治的94例慢性阻塞性肺疾病稳定期患者,按随机数字表法分为两组,各47例。对照组给予布地奈德治疗,观察组加以益气宣肺汤加减治疗。对比两组临床疗效、免疫功能、肺功能、不良反应。结果:观察组治疗总有效率为95.74%(45/47),高于对照组的80.85%(38/47),差异有统计学意义(P<0.05)。治疗前,两组CD3+、CD4+、CD8+、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、呼气流量峰值(PEF)对比,差异均无统计学意义(P>0.05);治疗后,观察组CD3+(70.63±7.25)%、CD4+(44.36±3.73)%、FVC(2.41±0.64)L、FEV1(1.92±0.37)L、PEF(389.75±23.46)L/min,均高于对照组的(64.59±6.31)%、(38.75±2.95)%、(1.98±0.58)L、(1.42±0.26)L、(330.69±19.36)L/min,CD8+(24.31±2.05)%,低于对照组的(28.63±2.42)%,差异均有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:益气宣肺汤加减联合布地奈德治疗慢性阻塞性肺疾病稳定期患者作用明显,可缓解各项症状,改善免疫功能,提升肺功能,无严重不良反应。

Objective:To analyze the therapeutic effect of modified Yiqi Xuanfei Decoction combined with Budesonide in patients with stable phase of chronic obstructive pulmonary disease.Method:A total of 94 patients with stable phase of chronic obstructive pulmonary disease admitted to Anshun Xixiu District People's Hospital from April 2021 to April 2023 were selected and divided into two groups according to random number table method,with 47 patients in each group.The control group was treated with Budesonide,and the observation group was treated with modified Yiqi Xuanfei Decoction.The clinical efficacy,immune function,lung function and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 95.74%(45/47),which was higher than 80.85%(38/47)of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in CD3+,CD4+,CD8+,forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and peak expiratory flow(PEF)between the two groups(P>0.05);after treatment,CD3+(70.63±7.25)%,CD4+(44.36±3.73)%,FVC(2.41±0.64)L,FEV1(1.92±0.37)L and PEF(389.75±23.46)L/min in the observation group were higher than(64.59±6.31)%,(38.75±2.95)%,(1.98±0.58)L,(1.42±0.26)L and(330.69±19.36)L/min in the control group,the CD8+[(24.31±2.05)%]was lower than(28.63±2.42)%of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Yiqi Xuanfei Decoction combined with Budesonide has an obvious effect in the treatment of patients with stable phase of chronic obstructive pulmonary disease,which can alleviate various symptoms,improve immune function,and enhance lung function,without serious adverse reactions.