结缔组织病相关性间质性肺疾病诊断的研究进展

Progress in Diagnosis of Connective Tissue Disease-Associated Interstitial Lung Disease

结缔组织病患者的诊治和预后有了显著改善,但CTD相关性间质性肺疾病(CTD-ILD)仍然是一种难治性疾病,在最严重的情况下,CTD-ILD会导致肺功能逐渐丧失、呼吸衰竭并最终死亡。早期诊断、早期介入治疗至关重要。文章回顾了目前对于CTD-ILD诊断的研究进展,如临床表现、血清标志物、肺功能、高分辨率CT(HRCT)、肺部超声、支气管镜检、肺部活检以及基因检查等,分析显示随着对CTD-ILD的诊断的不断探索,CTD-ILD的诊断的方式越来越多,但还需要更多的研究使CTD-ILD的诊断能够简便且精确,希望未来的研究将为精准医学铺平道路,为更准确的CTD-ILD诊断提供数据,从而指导医生进行有针对性的治疗,改善患者预后。

In recent years,the diagnosis,treatment and prognosis of connective tissue disease(CTD)have been improved significantly.However,CTD-associated interstitial lung disease(CTD-ILD)remains a refractory disease.In the most severe cases,CTD-ILD can result in progressive loss of lung function,respiratory failure,and eventually death.Therefore,early diagnosis and interventional therapy are crucial for CTD-ILD.This article reviews the current research progress in the diagnosis of CTD-ILD,such as clinical manifestations,serum markers,lung function,high resolution CT,lung ultrasound,bronchoscopy,lung biopsy and genetic examination.With the continuous exploration of the diagnosis of CTD-ILD,there has been an increase in the ways to diagnose CTD-ILD.Nevertheless,more studies are needed to make the diagnosis of CTD-ILD simple and accurate.Future research will pave the way for precision medicine and provide data for more accurate CTD-ILD diagnosis,thus guiding doctors to carry out targeted treatment and improving patient prognosis.