平足蛋白参与炎症反应的研究进展

Research progress on the involvement of podoplanin in inflammatory response

平足蛋白(podoplanin,PDPN)是一种较为保守的唾液酸跨膜黏蛋白,常表达于个体发育中的成纤维细胞、肺泡细胞和肾小球足细胞等不同类型的细胞组织当中,参与个体的胚胎发育、免疫反应、癌症恶性进展等过程。急性炎症是机体受到刺激时产生的一系列红、肿、热、痛的防御反应,对于机体有一定的保护作用,但当急性炎症逐步发展为慢性炎症时会对机体产生一定的有害影响而导致疾病的产生。近年来研究表明当机体产生炎症时,PDPN在各细胞组织中的表达上调,如成纤维细胞、T细胞以及巨噬细胞等,也多表达于炎症性疾病,如多发性硬化症、类风湿性关节炎和系统性硬化症等,而且PDPN主要通过与其相邻的细胞或蛋白相互作用,来调节细胞的增殖、收缩、迁移、定植等行为参与炎症性疾病的发生发展。而静脉血栓的形成与炎症密切相关,PDPN在炎症驱动血栓的形成过程中起到了一定的作用。本文主要将对PDPN的结构、功能和在炎症中的功能及作用机制的研究作一综述。

Podoplanin(PDPN)is a relatively conserved sialic acid transmembrane mucin,which is often expressed in different types of cell tissues such as fibroblasts,alveolar cells and glomerular podocytes in ontoge⁃netic development,and participates in the embryonic development,immune response,and malignant progression of cancer.Acute inflammation is a series of red,swollen,hot,painful defense reactions when the body is stimulated,which has a certain protective effect on the body,but when acute inflammation gradually develops into chronic inflammation,it will have a certain harmful effect on the body and lead to disease.In recent years,studies have shown that when the body produces inflammation,the expression of PDPN in various cell tissues is upregulated,such as fibroblasts,T cells and macrophages,etc.,and is also expressed in inflammatory diseases,such as multiple sclerosis,rheumatoid arthritis and systemic sclerosis,and PDPN mainly interacts with adjacent cells or proteins to regulate cell proliferation,contraction,migration,colonization and other behaviors to participate in the occurrence and development of inflammatory diseases.This article will mainly review the structure,function,function and mechanism of PDPN in inflammation.