原发性高血压患者血清自噬相关蛋白9a、半乳糖凝集素-3与左心室肥厚的相关性

Correlation of serum autophagy⁃related protein 9a and galectin⁃3 with left ventricular hypertrophy in essential hypertension patients

目的 探讨原发性高血压(EH)患者血清自噬相关蛋白9a(ATG9a)、半乳糖凝集素-3(Gal-3)与左心室肥厚(LVH)的关系。方法 前瞻性选取2020年7月至2022年12月在西南医科大学附属中医医院体检的原发性高血压患者84例(NLVH组)和原发性高血压合并左心室肥厚(LVH组)患者69例,同时纳入115例健康体检人群为对照组。分析原发性高血压患者血清ATG9a、Gal-3水平与左心室肥厚的相关性。结果 与对照组比较,NLVH组与LVH组合并冠心病比例、合并血脂异常比例、BMI、收缩压、舒张压、同型半胱氨酸、丙氨酸氨基转移酶、甘油三酯、总胆固醇、空腹血糖、左心室舒张末期后壁厚度(LVPWTD)、舒张末期室间隔厚度(IVSTD)、左心室质量指数(LVMI)、ATG9a、Cal-3显著增高,HDL-C显著降低(P<0.05);与NLVH组比较,LVH组高血压病程、收缩压、舒张压、LVPWTD、左心室舒张末期内径(LVEDD)、IVSTD、LVMI、ATG9a、Cal-3显著增高,差异有统计学意义(P<0.05)。ROC曲线显示,血清ATG9a、Cal-3水平的曲线下面积分别为0.829(95%CI:0.765~0.893)、0.819(95%CI:0.753~0.884),差异有统计学意义(P<0.001)。结论 原发性高血压患者血清ATG9a、Cal-3水平与左心室肥厚存在相关性,ATG9a、Cal-3可作为临床上辅助诊断、评估原发性高血压合并左心室肥厚的指标之一。

Objective To investigate the correlation of serum autophagy-related protein 9a(ATG9a)and galectin-3(Gal-3)with left ventricular hypertrophy(LVH)in essential hypertension(EH)patients.Methods A total of 84 patients with EH(NLVH group)and 69 patients with EH combined with LVH(LVH group)who underwent physical examination at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical Universityfrom July 2020 to December 2022 were recruited prospectively,and another 115 healthy individuals who taking physical examination during the same period were included as the control group.The correlation of serum ATG9a and Gal-3 levels with LVH was analyzed in the patients with EH.Results Compared with the control group,the NLVH group and LVH group had significantly higher proportion of combined coronary heart disease and proportion of combined dyslipidemia,abnormal body mass index,increased systolic and diastolic blood pressure and homocysteine,alanine aminotransferase,triglycerides,total cholesterol,fasting blood glucose,LVPWTD,IVSTD,LVMI,and elevated ATG9a and Cal-3 level,but lower HDL-C level(P<0.05).Obviously longer course of hypertension,increased systolic and diastolic blood pressure,LVPWTD,LVEDD,IVSTD,LVMI,ATG9a,and Cal-3 in the LVH group were observed when compared with those in the NLVH group(P<0.05).ROC curve analysis showed that the areas under the curve for serum ATG9a and Cal-3 level was 0.829(95%CI:0.765~0.893)and 0.819(95%CI:0.753~0.884),respectively,with significant differences(P<0.001).Conclusion Serum ATG9a and Cal-3 are correlated with LVH in patients with EH,and they can be regarded as clinical indicators in the auxiliary diagnosis and prognostic assessment for patients with EH with LVH.