肿瘤相关中性粒细胞的双向调控作用及其在膀胱尿路上皮癌中的研究进展

Bidirectional regulation of tumor associated neutrophils and their role in urothelial bladder cancer:a literature review

膀胱尿路上皮癌(urothelial bladder cancer,UBC)是泌尿外科最常见的恶性肿瘤之一,其发生和进展与肿瘤微环境(tumor microenvironment,TME)密切相关。肿瘤相关中性粒细胞(tumor-associated neutrophils,TAN)作为TME中重要的一类免疫细胞,被证实在多种肿瘤中具有抑癌或促癌的调控作用,这种双向调控的产生与其异质性和可塑性有关,对TAN双向调控的研究有望为肿瘤治疗提供新的靶点。本文概述了TAN双向调控的研究现状,并对其在UBC中的研究进展进行综述。

Urothelial bladder cancer(UBC)is one of the most common malignant tumors in urology,and its occurrence and progression are closely related to the tumor microenvironment(TME).Tumor-associated neutrophils(TAN),as an important type of immune cells in TME,have been proven to have anti-tumor or pro-tumor regulatory effects on various tumors,which are related to their heterogeneity and plasticity.The study on TAN′s bidirectional regulation may provide new targets for tumor treatment.This article reviews the current status of TAN′s bidirectional regulation research by searching recent literature,and summarizes its research progress in UBC.