原发性胆汁性胆管炎胆管上皮细胞凋亡因素及机制的研究进展

Research progress on factors and mechanisms of apoptosis of bile duct epithelial cells in primary biliary cholangitis

原发性胆汁性胆管炎(primary biliary cholangitis,PBC)是一种慢性进展的自身免疫性肝病。目前治疗PBC的药物有限,且部分患者因对药物应答不佳等而最终进展至终末期肝病。PBC的发病机制尚不完全清楚,但越来越多证据表明胆管上皮细胞(bile duct epithelial cell,BEC)凋亡在PBC的发病机制中具有重要作用。本文综述PBC时影响BEC凋亡的主要因素及相关机制,旨在为PBC患者开发新的治疗靶点、新药物研发或新治疗方案的提出提供一定的理论基础。

Primary biliary cholangitis(PBC)is a chronically progressive autoimmune liver disease.At present,There are limited drugs to treat PBC,and some patients eventually progress to end-stage liver disease due to poor response to drugs.The pathogenesis of PBC is not fully understood,but there is increasing evidence that apoptosis of bile duct epithelial cell(BEC)plays an important role in the pathogenesis of PBC.This article reviewed the main factors and related mechanisms affecting BEC apoptosis in PBC,aiming to provide a theoretical basis for developing new therapeutic targets,developing new drugs or proposing new therapeutic schemes for PBC patients.