帕瑞昔布钠联合双歧杆菌四联活菌用于结直肠癌术后临床评价

Clinical Evaluation of Parecoxib Sodium Combined with Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus,Live for Postoperative Treatment of Colorectal Cancer

目的探讨帕瑞昔布钠联合双歧杆菌四联活菌对结直肠癌术后患者胃肠功能、炎性反应的临床疗效。方法选取黄冈市中心医院2020年6月至2022年6月收治拟行结直肠癌手术的患者102例,按随机数字表法分为对照组和观察组,各51例。两组患者均予双歧杆菌四联活菌片口服,观察组患者加予注射用帕瑞昔布钠缓慢静脉注射。两组均连续治疗7 d。结果观察组总有效率为90.20%,显著高于对照组的68.63%(P<0.05)。与对照组比较,观察组患者治疗后的首次排气时间、首次排便时间、肠鸣音恢复正常时间均显著缩短,视觉模拟评分法评分显著降低,大肠杆菌、C反应蛋白、白细胞介素6、肿瘤坏死因子-α水平均显著降低,双歧杆菌、乳酸杆菌、粪肠球菌、血清胃泌素、胃动素水平均显著升高(P<0.05)。观察组与对照组不良反应发生率相当(17.65%比7.84%,P>0.05)。结论帕瑞昔布钠联合双歧杆菌四联活菌可改善结直肠癌术后患者的胃肠功能,减轻机体炎症情况及疼痛程度。

Objective To investigate the clinical efficacy of parecoxib sodium combined with combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus,live in gastrointestinal function and inflammatory reaction of patients undergoing colorectal cancer surgery.Methods A total of 102 patients planned to undergo colorectal cancer surgery in the Huanggang Central Hospital from June 2020 to June 2022 were selected and divided into the control group and the observation group by the random number table method,with 51 cases in each group.Both groups received Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus Tablets,Live orally,on this basis,the patients in the observation group received slow intravenous injection of Parecoxib Sodium for Injection.Both groups were treated continuously for 7 d.Results The total effective rate in the observation group was 90.20%,which was significantly higher than 68.63%in the control group(P<0.05).Compared with those in the control group,the time to first exhaust,the time to first defecation and the recovery time of bowel sounds after treatment in the observation group significantly shortened(P<0.05).Compared with that in the control group,the visual analogue scale(VAS)score after treatment in the observation group significantly decreased(P<0.05).Compared with those in the control group,the Escherichia coli,C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)levels in the observation group significantly decreased(P<0.05).Compared with those in the control group,the Bifidobacterium,Lactobacillus,Enterococcus faecalis,serum gastrin(GAS)and motilin(MTL)levels in the observation group significantly increased(P<0.05).The incidence of adverse reactions in the observation group and control group was similar(17.65%vs.7.84%,P>0.05).Conclusion Parecoxib sodium combined with combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus,live can improve gastrointestinal function,relieve inflammatory reaction and pain degree in patients undergoing colorectal cancer surgery.