注射用益气复脉(冻干)联合阿托伐他汀治疗冠心病合并心力衰竭的疗效分析

Therapeutic effect of Yiqi Fumai Lyophilized Injection combined with atorvastatin on coronary heart disease with heart failure

目的探讨注射用益气复脉(冻干)联合阿托伐他汀治疗冠心病并心力衰竭的临床效果。方法选取2021年4月-2023年4月贵州省第二人民医院收治的100例冠心病合并心力衰竭患者为研究对象,根据治疗方案不同分为对照组和试验组,每组各50例。对照组在常规治疗基础上口服阿托伐他汀钙片,每次20 mg,每日1次;试验组在对照组基础上加用注射用益气复脉(冻干),每次5.2 g加入250~500 mL 5%葡萄糖注射液或0.9%氯化钠注射液稀释后静脉滴注,每日1次,两组均连续用药14d。观察两组患者的疗效,比较治疗前后两组患者心功能指标[脑钠肽(BNP)、左室射血分数(LVEF)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)]变化,观察治疗期间不良反应发生情况。结果试验组治疗总有效率96.0%,显著高于对照组82.0%(P<0.05)。治疗前,两组患者心功能指标及血脂指标比较,差异均无统计学意义(P>0.05)。治疗后,两组患者血清BNP、TC和LDL-C水平均较本组治疗前显著降低(P<0.05),LVEF水平均较本组治疗前显著升高(P<0.05),且试验组与对照组比较,上述各项指标改善效果更显著(P<0.05)。治疗期间,两组患者均各有3例患者出现轻度恶心,不良反应总发生率比较,差异无统计学意义(P>0.05)。结论注射用益气复脉(冻干)联合阿托伐他汀钙片治疗冠心病合并心力衰竭疗效显著,可改善患者心功能及血脂,安全性较高。

Objective To investigate the clinical effect of Yiqi Fumai Lyophilized Injection combined with atorvastatin in the treatment of coronary heart disease with heart failure.Method A total of 100 patients with coronary heart disease and heart failure admitted to the Second People's Hospital of Guizhou Province from April 2021 to April 2023 were selected as the research subjects.They were divided into a control group and an experimental group based on different treatment plans,with 50 patients in each group.Patients in the control group took orally Atorvastatin Calcium Tablets,20 mg each time,once a day on the basis of conventional treatment.Patients in the experimental group was supplemented with injection of Yiqi Fumai Lyophilized Injection on the basis of the control group.Each time,5.2 g was added,and 250—500 mL of 5%Glucose Injection or 0.9%Sodium Chloride Injection was diluted before intravenous drip,once a day.Both groups were treated continuously for 14 days.The curative effect of the two groups of patients was observed.The cardiac function indicators[brain natriuretic peptide(BNP),left ventricular ejection fraction(LVEF)],blood lipid indicators[total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]of the two groups of patients were compared before and after treatment.The occurrence of adverse reactions was observed during treatment.Results The total effective rate of the experimental group was 96.0%,significantly higher than the control group's 82.0%(P<0.05).Before treatment,there was no statistically significant difference(P>0.05)in the comparison of cardiac function indicators and blood lipid indicators between the two groups of patients(P>0.05).After treatment,the serum levels of BNP,TC,and LDL-C in both groups of patients were significantly reduced compared to before treatment in same group(P<0.05),and the LVEF levels were significantly increased compared to before treatment in same group(P<0.05).Moreover,compared with the control group,the improvement effect of the above indicators in the experimental group was more significant(P<0.05).During the treatment period,both groups of patients had three cases of mild nausea,and there was no statistically significant difference in the total incidence of adverse reactions(P>0.05).Conclusion Yiqi Fumai Lyophilized Injection combined with Atorvastatin Calcium Tablet is effective in the treatment of coronary heart disease with heart failure,and can improve the heart function and blood lipids of patients with high safety.