临床检验常规数据与干性年龄相关性黄斑变性的相关性研究

The correlation between clinical laboratory routine data and dry age-related macular degeneration

目的 探索临床检验常规数据与干性年龄相关性黄斑变性(AMD)的相关性。方法 选取2017年1月~2022年12月于上海市徐汇区中心医院就诊并确诊为干性AMD的患者作为病例组,收集同时间段在本院体检的人群作为对照组。通过病史系统和LIS系统收集2组人群人口学资料和临床常规检验数据。二元Logistic回归分析临床常规检验数据与干性AMD的相关性。运用LASSO回归筛选特征性临床检验指标,绘制受试者工作特征曲线评估临床常规检验数据在干性AMD中的临床价值。结果 本研究共纳入干性AMD患者223例,对照组420例。中性粒细胞计数(NE)、红细胞计数(RBC)、血小板计数、血红蛋白、嗜酸性粒细胞计数(EOS)、嗜碱性粒细胞计数、淋巴细胞计数、红细胞比容、平均血小板体积、白细胞计数、红细胞平均分布宽度(RDW)、平均红细胞体积、平均红细胞血红蛋白浓度在干性AMD组和对照组间比较,差异有统计学意义(P<0.05)。Logistic回归分析显示,NE、RBC、EOS、平均红细胞体积、红细胞比容、平均红细胞血红蛋白浓度是干性AMD发病的危险因素。LASSO回归分析显示,NE、RBC、EOS和RDW是干性AMD发病的特征性指标,Y=0.081 94×NE-0.264 16×RBC-0.481 45×EOS+0.013 68×RDW_CV,诊断AMD的曲线下面积为0.701。结论 临床检验常规数据与干性AMD具有一定的相关性,可能是干性AMD发生、发展的危险因素。

Objective To explore the correlation between clinical laboratory routine data and dry age-related macular degeneration(AMD).Methods Patients diagnosed with AMD in Xuhui District Central Hospital of Shanghai from January 2017 to December 2022 were selected as the case group,and people who had undergone physical examination in our hospital during the same period of time were collected as the control group.Demographic data and clinical routine test data of the two groups were collected through the medical history system and LIS system.Binary logistic regression was used to analyze the correlation between clinical laboratory routine and AMD.LASSO regression was used to screen characteristic clinical test indicators,and the receiver operating characteristic(ROC)curve was drawn to evaluate the clinical value of clinical routine test data.Results A total of 223 patients with dry AMD and 420 controls were enrolled in this study.There were significant differences in NE,RBC,PLT,HB,EOS,BASO,LYM,HCT,MPV,WBC,RDW,MCV,and MCHC levels between the dry AMD group and the control group(P<0.05).Logistic regression analysis showed that NE,RBC,EOS,MCV,HCT,and MCHC were risk factors for dry AMD.LASSO regression analysis showed that NE,RBC,EOS and RDW were characteristic indicators of dry AMD,Y=0.08194×NE-0.26416×RBC﹣0.48145×EOS+0.01368×RDW_CV,and the area under the curve for diagnosis of AMD was 0.701.Conclusions There is a correlation between dry AMD and routine clinical laboratory data,which may be a risk factor for the occurrence and development of dry AMD.