中医药古籍中疫病咽喉症状用药规律探析

Analysis of medication rules for throat symptoms of epidemic diseases in ancient traditional Chinese medicine literature

目的基于中医药古籍中的疫病咽喉症状相关内容,挖掘古代医家治疗疫病咽喉症状的用药经验。方法基于45部中医药古籍,建立包含518条标准化、结构化数据的疫病咽喉症状数据表,使用频次统计、关联规则、二项Logistic回归等方法对症状与用药的相关性、规律性进行统计分析。结果纳入数据以咽喉痛、发热、咽喉肿等症状居多,以甘草、桔梗、连翘等药物居多。疫病咽喉症状与其他症状存在一定相关性,如咽喉痛、咽喉肿、发热常同时出现。疫病咽喉症状的用药配伍存在较强规律性,常用药对有黄连-黄芩等。针对疫病中不同的咽喉症状,使用概率较大的中药有所不同,如咽红症状,使用概率较大的中药为制半夏、金银花、荆芥。结论古代医家在治疗伴有咽喉症状的疫病时,用药配伍存在较强的规律性;针对不同的疫病咽喉症状,有不同的用药偏好。

Objective Based on the relevant contents of throat symptoms of epidemic diseases in ancient traditional Chinese medicine literature,the medication experience of ancient doctors in treating throat symptoms of epidemic diseases was explored.Methods Based on 45 ancient books of traditional Chinese medicine,a data table of throat symptoms of epidemic diseases containing 518 standardized structured data was established,and the correlation regularity between symptoms and medication was statistically analyzed using frequency statistics,association rules and binomial logistic regression.Results The included data were mainly characterized by sore throat,fever,swollen throat and other symptoms,and mainly by Gancao,Jiegeng,Lianqiao and other medicine.There is a correlation between throat symptoms and other symptoms,such as sore throat,swollen throat,and fever often occurring together.There is a strong regularity in the medicine compatibility of throat symptoms of epidemic diseases.The commonly used couplet medicines include Huanglian-Huangqin and so on.For different throat symptoms in epidemic diseases,there are different traditional Chinese medicine with high probability of use.For example,for the symptom of pharyngeal redness,the traditional Chinese medicine with high probability of use is Zhibanxia,Jinyinhua and Jingjie.Conclusion When ancient doctors treat epidemic diseases with throat symptoms,there is a strong regularity in medicine compatibility;for different throat symptoms of epidemic diseases,there are different medicine preferences.