基于苯并噻二唑结构的近红外二区有机小分子在生物成像和治疗中的研究进展

Advances of NIR-ⅡSmall Organic Molecules in Bioimaging and Therapy Based on Benzothiadiazole Structure

基于光子反射、散射和自发荧光的减弱,近红外二区窗口能够实现高分辨率和信噪比的生物荧光成像,在各种生物医学应用中发挥着重要作用。构建供体-受体-供体结构是设计近红外二区有机小分子的有效方法,基于苯并噻二唑结构的近红外二区有机小分子不仅能够实现光学成像,还能利用光激活的激发态能量转换实现光学治疗。本文总结了基于苯并双噻二唑(Benzobisthiadiazole,BBT)和[1,2,5]噻二唑[3,4-g]喹喔啉([1,2,5]thiadiazolo[3,4-g]quinoxaline,TQ)结构的近红外二区有机小分子在生物成像和成像引导的治疗中的研究进展,并对未来近红外二区有机小分子的设计和应用进行了展望。

Based on the reduction of photon reflection,scattering and spontaneous fluorescence,NIR-Ⅱwindow enables high resolution and signal-to-noise ratio biofluorescence imaging,which plays an important role in a variety of biomedical applications.The construction of donor-acceptor-donor structure is an effective method for the design of NIR-Ⅱsmall organic molecules.NIR-Ⅱsmall organic molecules based on benzothiadiazole structure can not only realize optical imaging,but also realize phototherapeutics by utilizing the light-activated excited state energy conversion.This review summarizes the research advances of NIR-Ⅱsmall organic molecules based on benzobisthiadiazole(BBT)and[1,2,5]thiadiazolo[3,4-g]quinoxaline(TQ)in bioimaging and image-guided therapy,and prospects of the design and application of NIR-Ⅱsmall organic molecules in the future are presented.