多拉司琼预防剖宫产腰麻后低血压的研究

Prevention of Hypotension after Spinal Anesthesia for Cesarean Delivery with Dolasetron

目的 探讨多拉司琼用于预防剖宫产腰麻后低血压的效果。方法 择期行腰麻下剖宫产患者,采用随机双盲对照试验,分为治疗组与对照组,每组40例。分别于麻醉前15 min静脉注射多拉司琼12.5 mg或生理盐水,观察两组产妇低血压、心动过缓、术中恶心呕吐发生率以及新生儿Apgar评分。结果 治疗组产妇低血压发生率及麻黄碱的使用率均低于对照组(30%VS 45%,P<0.05),治疗组产妇术中恶心呕吐的发生率明显低于对照组(P<0.05)。两组心动过缓的发生率、新生儿Apgar评分比较差异无统计学意义(P>0.05)。结论 多拉司琼可有效降低剖宫产腰麻后低血压、降低麻黄碱的使用率,减少术中产妇恶心呕吐的发生。

OBJECTIVE To investigate the effect of dolasetron on the prevention of hypotension after spinal anesthesia for cesarean delivery.METHODS Patients undergoing elective cesarean delivery under spinal anesthesia were randomly divided into treatment group and control group with 40 cases in each group.Dolasetron 12.5 mg or normal saline was injected intravenously 15 min before anesthesia,respectively.The incidence of hypotension,bradycardia,intraoperative nausea and vomiting,and neonatal Apgar score were observed.RESULTS The incidence of maternal hypotension and the use of ephedrine were lower in the treatment group than in the control group(30%vs.45%,P<0.05),and the incidence of intraoperative nausea and vomiting was significantly lower in the treatment group than in the control group(P<0.05).There was no statistically significant difference in the incidence of bradycardia and neonatal Apgar score between the two groups(P>0.05).CONCLUSION Dolasetron is effective in reducing hypotension after spinal anesthesia for cesarean delivery,decreasing the use of ephedrine,and reducing the occurrence of intraoperative maternal nausea and vomiting.