抑郁症患者血清尿酸降低与认知功能障碍的相关性

The correlation between reduced serum uric acid levels and cognitive impairment in patients with depressive disorder

目的:探索抑郁症患者血清尿酸变化及其与认知损伤之间的关系。方法:选取2022年1月至2022年12月温州市第七人民医院抑郁症住院患者及健康人共110例,分为抑郁症组(55例)及健康对照组(55例),采用重复性成套神经心理状态监测量表(RBANS)测量所有被试的认知功能,包括即刻记忆、视觉空间、言语功能、注意功能和延迟记忆,并检测血清尿酸。结果:控制协变量后,抑郁症组血清尿酸、即刻记忆、注意功能、言语功能、延迟记忆和RBANS总分均低于对照组,差异有统计学意义(P<0.05);经过Bonferroni矫正后,2组间即刻记忆、言语功能和注意功能的差异仍有统计学意义(P<0.05)。抑郁症组血清尿酸与即刻记忆(r=0.315,P=0.019)、注意功能(r=0.401,P=0.002)、言语功能(r=0.353,P=0.008)、延迟记忆(r=0.412,P=0.002)和RBANS总分(r=0.397,P=0.003)呈正相关。多元线性回归分析提示抑郁症组血清尿酸与言语功能(B=0.127,P=0.044)和注意功能(B=0.166,P=0.036)存在正相关。结论:降低的血清尿酸可能参与抑郁症认知损伤的病理过程。

Objective:To explore the changes in serum uric acid(SUA)levels and their relationship with cognitive impairment in patients with depression.Methods:A total of 110 depressive patients and healthy adults were recruited from January 2022 to December 2022 at the Seventh People’s Hospital of Wenzhou,who were divided as depression group(55)and a healthy control group(55).Repeatable Battery for the Assessment of Neuropsychological(RBANS)was used to assess the cognitive functions of the two groups,including immediate memory,visuospatial,language function,attention function,delayed memory,and SUA levels were also estimated.Results:After controlling covariates,the SUA levels,immediate memory,attention function,language function,delayed memory,and total RBANS score of the depression group were lower than those of the control group,with statistically significant difference(P<0.05).After Bonferroni correction,there were still significant differences between the two groups in immediate memory,language function,and attention(P<0.05).There was a positive correlation between SUA levels and immediate memory(r=0.315,P=0.019),attention function(r=0.401,P=0.002),language function(r=0.353,P=0.008),delayed memory(r=0.412,P=0.002),and RBANS total score(r=0.397,P=0.003)in the depression group.Multiple linear regression suggested a positive correlation between SUA levels and language(B=0.127,P=0.044)and attention function(B=0.166,P=0.036)in patients with depression.Conclusion:Our results suggest that reduced SUA levels might be implicated in the pathophysiology of cognitive impairment in depressive disorder.