二尖瓣反流对主动脉瓣流体动力学性能影响的试验研究

Experimental Study on Effects of Mitral Regurgitation on Hydrodynamic Performance of Aortic Valve

目的有关心脏瓣膜之间相互影响的研究在临床上开展相对受限,体外测试的数据也尚显不足。该文利用可精细控制反流量的二尖瓣反流模型对一种主动脉瓣膜进行体外流体动力学性能研究。方法在固定心率、每搏输出量以及平均主动脉压的条件下,逐步增加二尖瓣反流模型的反流量,对待测主动脉瓣膜进行流体动力学性能测试。结果借助二尖瓣反流模型对机械式主动脉瓣膜(25AJ-501)的流体动力学性能进行研究发现,主动脉瓣膜的有效瓣口面积及跨瓣压差均与二尖瓣反流程度的大小存在负相关关系。结论建立的借助可精细调节反流量的二尖瓣反流模型的测试方法,可以用于二尖瓣反流对主动脉瓣膜流体动力学性能的研究。

Objective Aims researches on the interaction between heart valves is limited in clinical.Meanwhile the data of in vitro testing are insufficient.In this study,the in vitro hydrodynamic performance of an aortic valve was studied by using a model of mitral regurgitation that could finely adjust the regurgitant volume.Methods The regurgitation of mitral valve was gradually increased under the certain condition of heart rate,stroke volume,and mean aortic pressure and captured the hydrodynamic performance of the aortic valve.Results The study on the hydrodynamic performance of mechanical aortic valve(25AJ-501)by using a model of mitral regurgitation found that the effective orifice area and mean pressure difference of the aortic valve are negatively correlated with the degree of mitral regurgitation.Conclusion The method based on a model of mitral regurgitation that could finely adjust the regurgitant volume established in this study can be used to study the effect of mitral valve regurgitation on the hydrodynamic performance of the aortic valve.