肺动脉高压动物模型及其在药物研究中的应用进展

Animal Models of Pulmonary Arterial Hypertension and Their Application in Drug Research

肺动脉高压是一种由肺血管重构引起血管阻力增大的临床综合征,若不治疗将导致右心衰竭,甚至死亡。目前关于肺动脉高压的病理机制尚未明确,且临床治疗方法未能有效改善预后或降低死亡率。为了深入研究肺动脉高压的发病机制并开发更加安全有效的药物,建立合适的疾病动物模型在临床前研究中必不可少。本文概述了肺动脉高压的病理特征,并总结了各类肺动脉高压动物模型,同时阐述了近5年内肺动脉高压动物模型在3种治疗途径及相关药物研究中的应用进展,以期为肺动脉高压动物模型的选择和研究应用提供参考。

Pulmonary arterial hypertension is a clinical syndrome characterized by pulmonary vascular remodeling causing increased vascular resistance,which will lead to right heart failure and even death if left untreated.The pathogenesis of pulmonary arterial hypertension has not yet been clarified,and clinical treatments have not been effective in improving prognosis or reducing mortality.To investigate the pathogenesis of pulmonary arterial hypertension and to develop and evaluate more effective and safer drug treatments,establishing related animal disease models is very important.This paper outlines the pathological characteristics of pulmonary arterial hypertension and summarizes the various types of animal models of pulmonary arterial hypertension,as well as describes the progress of the application of these models in three therapeutic pathways and related drug research in the past five years,with a view to providing a reference for the selection of animal models of pulmonary arterial hypertension and research applications.